CerivastatinisaninhibitorofHMG-CoAreductasethatexhibitsanti-hyperlipidemic,anti-atherosclerotic,anti-fibrotic,andanti-inflammatoryactivities.Cerivastatinhasbeenusedclinicallytolowercholesterolandtreatcardiovasculardisease,buthassincebeenwithdrawnfromthemarketduetoassociationswiththedevelopmentofrhaBDomyolysis.Invitro,cerivastatindecreasesproductionandactivationofIL-6,AP-1,andNF-κB.Inhepatocytes,thiscompounddecreasesTNF-α-inducedproductionofPAI-1,preventingatherosclerosisandfibrosis.
| CasNo. | 143201-11-0 |
|---|---|
| Purity | ≥98% |
| Formula | C26H33FNO5Na |
| FormulaWt. | 481.53 |
| ChemicalName | (3R,5S,6E)-7-[4-(4-Fluorophenyl)-5-(methoxymethyl)-2,6-bis(1-methylethyl)-3-pyridinyl]-3,5-dihydroxy-6-heptenoicacid |
| IUPACName | sodium;(E,3R,5S)-7-[4-(4-fluorophenyl)-5-(methoxymethyl)-2,6-di(propan-2-yl)pyridin-3-yl]-3,5-dihydroxyhept-6-enoate |
| Synonym | Baycol;Lipobay;Rivastatin |
| Solubility | Solubleinwater. |
| Appearance | Whitetooffwhitepowder |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| MSDS | C1668MSDSPDF |
|---|---|
| InfoSheet | C1668InfoSheetPDF |
| Brochures | StatinsFlyer |
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SchachterM.Chemical,pharmacokineticandpharmacodynamicpropertiesofstatins:anupdate.FundamClinPharmacol.2005Feb;19(1):117-25.PMID:15660968.
JamalSM,EisenbergMJ,ChristopoulosS.Rhabdomyolysisassociatedwithhydroxymethylglutaryl-coenzymeAreductaseinhibitors.AmHeartJ.2004Jun;147(6):956-65.PMID:15199341.
ViedtC,ShenW,FeiJ,etal.HMG-CoAreductaseinhibitionreducestheproinflammatoryactivationofhumanvascularsmoothmusclecellsbytheterminalcomplementfactorC5b-9.BasicResCardiol.2003Nov;98(6):353-61.PMID:14556080.
