Chloroadenosineisanucleosideanalogthatexhibitsanticancer,vasodilatory,andanti-inflammatoryactivities.Chloradenosineinducesdouble-strandedDNAbreaksandapoptosisinlungcancercells.ThiscompoundactsasanagoNISTatadenosinereceptors,inducingarterialdilation.InanimalmodelsoflunginjuryinducedbylatexparticlesandEscherichiaexposure,chloroadenosinedecreasesexpressionofTNF-α.
| CasNo. | 146-77-0 |
|---|---|
| Purity | ≥98% |
| Formula | C10H12ClN5O4 |
| FormulaWt. | 301.69 |
| IUPACName | (2R,3R,4S,5R)-2-(6-amino-2-chloropurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol |
| Synonym | 2-Chloroadenosine;2-CADO;6-Amino-2-chloropurineriboside |
| MeltingPoint | 162°C |
| Solubility | Solubleinmethanol. |
| Appearance | Whitepowder |
| StoreTemp | Ambient |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | C2948InfoSheetPDF |
|---|
DuanHY,CaoJX,QiJJ,etal.E2F1enhances8-chloro-adenosine-inducedG2/MarrestandapoptosisinA549andH1299lungcancercells.Biochemistry(Mosc).2012Mar;77(3):261-9.PMID:22803943.
BenderSB,TuneJD,BorbouseL,etal.Alteredmechanismofadenosine-inducedcoronaryarteriolardilationinearly-stagemetabolicsyndrome.ExpBiolMed(Maywood).2009Jun;234(6):683-92.PMID:19307464.
SakamakiF,IshizakaA,UranoT,etal.Attenuationbyintravenous2-chloroadenosineofacutelunginjuryinducedbyliveescherichiacoliorlatexparticlesaddedtoendotoxinintheneutropenicstate.JLabClinMed.2003Aug;142(2):128-35.PMID:12960960.
