LKT/CHLOROGENIC ACID (FROM EUCOMMIA)/C2943/250 mg-免疫在线蚂蚁淘旗下平台

商品详细LKT/CHLOROGENIC ACID (FROM EUCOMMIA)/C2943/250 mg

LKT/CHLOROGENIC ACID (FROM EUCOMMIA)/C2943/250 mg

商品编号： C2943-250mg

品牌： lktlabs

市场价： ¥880.00

美元价： 528.00

产地：美国(厂家直采)

公司：

产品分类：临床研究

公司分类： clinical_research

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

ProductIDC2943

CasNo.327-97-9

Purity≥98%

Description
ProductInfo
ShippingandStorage
Downloads
References

Description

ChlorogenicacidisapolyphenolderivativeofcaffeicacidfoundinEucommiabarkthatexhibitsawidevarietyofbeneficialproperties,includingantibacterial,antioxidative,anti-inflammatory,hepatoprotective,neuroprotective,anti-allergic,anticancerchemotherapeutic,andchemopreventiveactivities.ChlorogenicacidaltersmembranestABIlityofbacteriasuchasStaphylococcus,andmayalsoinhibitpepsinactivity.Chlorogenicacidalsopreventsacetaminophen-inducedliverinjury,preventingactivationofcaspases3and7aswellasphosphorylationofERK1/2,JNK,andp38MAPK;italsoincreaseslevelsofglutathioneandthioredoxinandincreasesactivityofglutathionereductaseandthioredoxinreductase,preventingoxidativestressandapoptosisinvitro.Insimilarinvivomodels,chlorogenicacidpreventsactivationofNF-κBanddecreasesexpressionoftoll-likereceptor4(TLR4),Myd88,iNOS,COX-2,TNF-α,IL-6,andIL-1β.Thiscompounddecreaseshistaminereleaseandinhibitsmastcellactivation,preventingsystemicanaphylaxis.Invitro,chlorogenicacidinhibitsdopamineoxidationandinteractionsbetweendopamineandα-synuclein,indicatingpotentialbenefitinthetreatmentofParkinson’sdisease.Additionally,thiscompoundinhibitsDNAmethyltransferase(DNMT)inanoncompetitivemannerandalsoinhibitsglucose-6-phosphatetranslocase,decreasingexpressionofmatrixmetalloproteinase2(MMP2)andinhibitinggliomacellmigration.

ProductInfo

CasNo.	327-97-9
Purity	≥98%
Formula	C₁₆H₁₈O₉
FormulaWt.	354.31
IUPACName	(1S,3R,4R,5R)-3-[(E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy-1,4,5-trihydroxycyclohexane-1-carboxylicacid
MeltingPoint	207-209°C
Appearance	Grayorwhitepowder

ShippingandStorage

StoreTemp	Ambient
ShipTemp	Ambient

Downloads

InfoSheet	C2943InfoSheetPDF
Brochures	EpigeneticModifiersBooklet

References

ZengHJ,LiangHL,YouJ,etal.Studyonthebindingofchlorogenicacidtopepsinbyspectralandmoleculardocking.Luminescence.2013Dec12.[Epubaheadofprint].PMID:24339327.

LuísA,SilvaF,SousaS,etal.Antistaphylococcalandbiofilminhibitoryactivitiesofgallic,caffeic,andchlorogenicacids.Biofouling.2014Jan;30(1):69-79.PMID:24228999.

ShiH,DongL,JiangJ,etal.Chlorogenicacidreducesliverinflammationandfibrosisthroughinhibitionoftoll-likereceptor4signalingpathway.Toxicology.2013Jan7;303:107-14.PMID:23146752.

TeraokaM,NakasoK,KusumotoC,etal.Cytoprotectiveeffectofchlorogenicacidagainstα-synuclein-relatedtoxicityincatecholaminergicPC12cells.JClinBiochemNutr.2012Sep;51(2):122-7.PMID:22962530.

LouZ,WangH,ZhuS,etal.Antibacterialactivityandmechanismofactionofchlorogenicacid.JFoodSci.2011Aug;76(6):M398-403.PMID:22417510.

QinHD,ShiYQ,LiuZH,etal.Effectofchlorogenicacidonmastcell-dependentanaphylacticreaction.IntImmunopharmacol.2010Sep;10(9):1135-41.PMID:20620227.

BelkaidA,CurrieJC,DesgagnésJ,etal.Thechemopreventivepropertiesofchlorogenicacidrevealapotentialnewroleforthemicrosomalglucose-6-phosphatetranslocaseinbraintumorprogression.CancerCellInt.2006Mar27;6:7.PMID:16566826.

LeeWJ,ZhuBT.InhibitionofDNAmethylationbycaffeicacidandchlorogenicacid,twocommoncatechol-containingcoffeepolyphenols.

品牌介绍

LKT Labs LKT Labs 是一家专注于防癌抗癌特殊化学品研究和开发的公司。主要提供：癌症药物、药物发现试剂盒、天然产物、广泛的生命科学研究试剂、定制合成。美国LKT Labs 是1988年在美国成立的，为全球提供先端的药物研发试剂、试剂盒、委托合成，并为药物生产企业提供原料，最近几年在农药、水产养殖业有很大程度的开发。在LKT Labs 可以找到在其他地方找不到的产品。试剂