Chromostatin is a peptide fragment representing chromogranin A (124-143). Chromostatin exhibits cardiomodulatory activity, inhibiting vasoconstriction in thoracic arteries and saphenous veins induced by K+, norepinephrine, and endothelin-1. Additionally, chromostatin inhibits catecholamine secretion in chromaffin cells through the activation of protein phosphatase 2A (PP2A).
| Purity | ≥95% |
|---|---|
| Formula | C78H120N24O35 |
| Formula Wt. | 1953.97 |
| Store Temp | -20°C |
|---|---|
| Ship Temp | Ambient |
| Info Sheet | C2971 Info Sheet PDF |
|---|
Garcia GE, Gabbai FB, O'Connor DT, et al. Does chromostatin influence catecholamine release or blood pressure in vivo? Peptides. 1994 Jan;15(1):195-7. PMID: 8015978.
Aardal S, Galindo E, Aunis D, et al. Human chromostatin inhibits endothelin-1-induced contractures in human blood vessels. Regul Pept. 1993 Aug 13;47(1):25-32. PMID: 8210519.
Galindo E, Zwiller J, Bader MF, et al. Chromostatin inhibits catecholamine secretion in adrenal chromaffin cells by activating a protein phosphatase. Proc Natl Acad Sci U S A. 1992 Aug 15;89(16):7398-402. PMID: 1323834.
