Description
ClofibricacidisametaboliteofclofibratethatactivatesPPARαreceptorsandinhibitsauxinactivity,exhibitinganti-hyperlipidemic,anti-angiogenic,anticancerchemotherapeutic,andherbicidalactivity.Clofibricacidaltersplanthormoneactivityandisusedasaplantgrowthregulator.Clofibricacidalsoinhibitsphosphatidylethanolaminesynthesis,decreasingproductionofcholesterolandactivityofHMG-CoAreductaseandACAT.Additionally,clofibricacidsuppressesproductionofprostaglandinE2(PGE2)andVEGF,decreasesvesseldensity,andinhibitstumorgrowthinanimalmodelsofovariancancer.
References
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Nishimaki-MogamiT,SuzukiK,OkochiE,etal.Bezafibrateandclofibricacidarenovelinhibitorsofphosphatidylcholinesynthesisviathemethylationofphosphatidylethanolamine.BiochimBiophysActa.1996Nov11;1304(1):11-20.PMID:8944746.
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