LKT/CLONIDINE HYDROCHLORIDE/C4558/1 g-免疫在线蚂蚁淘旗下平台

商品详细LKT/CLONIDINE HYDROCHLORIDE/C4558/1 g

LKT/CLONIDINE HYDROCHLORIDE/C4558/1 g

商品编号： C4558-1g

品牌： lktlabs

市场价： ¥3740.00

美元价： 2244.00

产地：美国(厂家直采)

公司：

产品分类：临床研究

公司分类： clinical_research

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

ProductIDC4558

CasNo.4205-91-8

Purity≥98%

Description
ProductInfo
ShippingandStorage
Downloads
References

Description

Clonidineisanα2-adrenergicreceptoragoNISTthatalsoactivatetheimidazoline1receptor,increasingdownstreamcatecholaminesynthesis.Clonidineexhibitsantihypertensive,neuromoduatory,cognitionenhancing,antinociceptive,analgesic,andantipsychoticactivities.Inhypertensiverats,clonidineincreasesbaroreceptorsensitivityanddecreasesbloodpressureandheartrate.Inotheranimalmodels,clonidineinhibitslongtermpotentiation(synapticplasticity)anddecreasesexcitatorypostsynapticpotentials(EPSPs)inthemedialprefrontalcortex(mPFC),apotentialmechanismbehindclonidine’sABIlitytodecreaseglutamaterelease.Clonidinealsoimprovesspatialmemoryimpairmentsinvivo.Thiscompoundisoccasionallyusedclinicallyforitsantipsychoticbenefitsandismostoftenusedtotreatattentiondeficithyperactivedisorder(ADHD)asaresultofitsactionsthatstemfrombindingpostsynapticα2-adrenergicreceptors.Invitro,clonidineinhibitsNav1.7Na+channels.Invivo,clonidinedecreasesmechanicalandthermalpaininamodelofchronicconstrictioninjury-inducedneuropathy,likelyduetoitsabilitytodownregulateexpressionofphosphorylatedNMDAreceptorsubunit1(pNR1).ClonidinealsodisplayssomesedativeactivityandinducesdownstreamactivationofhistamineH2receptors.

ProductInfo

CasNo.	4205-91-8
Purity	≥98%
Formula	C₉H₉Cl₂N₃•HCl
FormulaWt.	266.55
IUPACName	N-(2,6-dichlorophenyl)-4,5-dihydro-1H-imidazol-2-amine;hydrochloride
MeltingPoint	130°C
Appearance	Whitetooffwhitepowder

ShippingandStorage

StoreTemp	Ambient
ShipTemp	Ambient

Downloads

MSDS	C4558MSDSPDF
InfoSheet	C4558InfoSheetPDF

References

LiCJ,ZhouM,LiHG,etal.Clonidinesuppressestheinductionoflong-termpotentiationbyinhibitingHCNchannelsattheschaffercollateral-CA1synapseinanesthetizedadultrats.CellMolNeurobiol.2013Nov;33(8):1075-86.PMID:23975095.

MarutaT,NemotoT,SatohS,etal.DexmedetomidineandclonidineinhibitthefunctionofNa(v)1.7independentofα(2)-adrenoceptorinadrenalchromaffincells.JAnesth.2011Aug;25(4):549-57.PMID:21607767.

RohDH,KimHW,YoonSY,etal.IntrathecalclonidinesuppressesphosphorylationoftheN-methyl-D-aspartatereceptorNR1subunitinspinaldorsalhornneuronsofratswithneuropathicpain.AnesthAnalg.2008Aug;107(2):693-700.PMID:18633054.

JiXH,JiJZ,ZhangH,etal.Stimulationofalpha2-adrenoceptorssuppressesexcitatorysynaptictransmissioninthemedialprefrontalcortexofrat.Neuropsychopharmacology.2008Aug;33(9):2263-71.PMID:17957212.

BardgettME,PointsM,Ramsey-FaulknerC,etal.Theeffectsofclonidineondiscrete-trialdelayedspatialalternationintworatmodelsofmemoryloss.Neuropsychopharmacology.2008Jul;33(8):1980-91.PMID:17882233.

MaXJ,ShenFM,LiuAJ,etal.Clonidine,moxonidine,folicacid,andmecobalaminimprovebaroreflexfunctioninstroke-prone,spontaneouslyhypertensiverats.ActaPharmacolSin.2007Oct;28(10):1550-8.PMID:17883939.

LiCG,RandMJ.Rilmenidinediffersfromclonidineinthatitlackshistamine-likeactivity.JPharmPharmacol.1989Jul;41(7):464-8.PMID:2570851.

ErnsbergerP,GiulianoR,WilletteRN,etal.Hypotensiveactionofclonidineanaloguescorrelateswithbindingaffinityatimidazoleandnotalpha-2-adrenergicreceptorsintherostralventrolateralmedulla.JHypertensSuppl.1988Dec;6(4):S554-7.PMID:2853758.

品牌介绍

LKT Labs LKT Labs 是一家专注于防癌抗癌特殊化学品研究和开发的公司。主要提供：癌症药物、药物发现试剂盒、天然产物、广泛的生命科学研究试剂、定制合成。美国LKT Labs 是1988年在美国成立的，为全球提供先端的药物研发试剂、试剂盒、委托合成，并为药物生产企业提供原料，最近几年在农药、水产养殖业有很大程度的开发。在LKT Labs 可以找到在其他地方找不到的产品。试剂