CoumarinisabenzopyronefoundinmanyplantssuchastheTonkabeanandsweetwoodruff.Coumariniscommonlyusedinperfumesandfabricconditionersforitssweetodor.Coumarinisaprecursorinthesynthesisofanticoagulantssuchaswarfarin;coumarininhibitsvitaminK.Coumarinisclinicallyusedtotreatedema,asitstimulatesmacrophagestodegradeextracellularalbumen,allowingincreasedfluidreabsorption.Coumarinisalsousedindyesandbio-imaging.Derivativesofcoumarinexhibitimmunomodulatory,anticancer,andantimicrobialactivities.
| CasNo. | 91-64-5 |
|---|---|
| Purity | ≥98% |
| Formula | C9H6O2 |
| FormulaWt. | 146.14 |
| ChemicalName | 2H-1-Benzopyran-2-one |
| IUPACName | chromen-2-one |
| Synonym | Cumarin;Coumarinicanhydride;Tonkabeancamphor |
| MeltingPoint | 68-70°C |
| Solubility | Slightlysolubleinwater.Solubleinalcohol,chloroform,ether,alkalihydroxidesolutionsoroils. |
| Appearance | Large,Semi-ClearCrystals |
| StoreTemp | Ambient |
|---|---|
| ShipTemp | Ambient |
| MSDS | C5782MSDSPDF |
|---|---|
| InfoSheet | C5782InfoSheetPDF |
KontogiorgisC,DetsiA,Hadjipavlou-LitinaD.Coumarin-baseddrugs:apatentreview(2008--present).ExpertOpinTherPat.2012Apr;22(4):437-54.PMID:22475457.
FarinolaN,PillerN.Pharmacogenomics:itsroleinre-establishingcoumarinastreatmentforlymphedema.LymphatResBiol.2005Summer;3(2):81-6.PMID:16000056.
