Dipropyl disulfide is an organosulfide found in Allium that exhibits antioxidative, anti-hyperlipidemic, and chemopreventive activities. Dipropyl disulfide induces phase II enzymes, increasing levels of glutathione-S-transferase in vitro. Dipropyl disulfide also decreases N-nitrosamine-induced DNA damage in vitro and suppresses benzo[a]pyrene-induced carcinogenesis in vivo. Additionally, this compound also inhibits cholesterol synthesis in vivo at low concentrations.
| Cas No. | 629-19-6 |
|---|---|
| Purity | ≥98% |
| Formula | C6H14S2 |
| Formula Wt. | 150.31 |
| IUPAC Name | 1-(propyldisulfanyl)propane |
| Synonym | 4,5-Dithiaoctane; Di-n-propyl disulfide; n-Propyl disulfide; Propyldithiopropane; n-Propyl disulfide; Propyl disulfide |
| Melting Point | -86°C |
| Solubility | Insoluble in water. |
| Appearance | Clear colorless liquid |
| Store Temp | Ambient |
|---|---|
| Ship Temp | Ambient |
| MSDS | D3261 MSDS PDF |
|---|---|
| Info Sheet | D3261 Info Sheet PDF |
Tsai CW, Liu KL, Lin CY, et al. Structure and function relationship study of allium organosulfur compounds on upregulating the pi class of glutathione S-transferase expression. J Agric Food Chem. 2011 Apr 13;59(7):3398-405. PMID: 21381664.
Arranz N, Haza AI, García A, et al. Protective effects of organosulfur compounds towards N-nitrosamine-induced DNA damage in the single-cell gel electrophoresis (SCGE)/HepG2 assay. Food Chem Toxicol. 2007 Sep;45(9):1662-9. PMID: 17434656.
Yeh YY, Liu L. Cholesterol-lowering effect of garlic extracts and organosulfur compounds: human and animal studies. J Nutr. 2001 Mar;131(3s):989S-93S. PMID: 11238803.
Srivastava SK, Hu X, Xia H, et al. Mechanism of differential efficacy of garlic organosulfides in preventing benzo(a)pyrene-induced cancer in mice. Cancer Lett. 1997 Sep 16;118(1):61-7. PMID: 9310261.
