Dipyridamoleisanon-selectiveinhibitorofphosphodiesterases(PDEs)thatincreaseslevelsofcAMPandcGMP;italsoinhibitsadenosinedeaminase.Dipyridamoleexhibitsvasodilatory,ati-thrombotic,andanti-inflammatoryactivities.Inmonocytes,dipyridamoledecreasesexpressionofmatrixmetalloproteinase9(MMP9)byinhibitingTNF-α-inducedNF-κBactivation,degradationofIkBα,andactivationofp38MAPK.Dipyridamolealsoinhibitsvascularstenosisbysuppressingproliferationofvenousandarterialsmoothmusclecells.
| CasNo. | 58-32-2 |
|---|---|
| Purity | ≥98% |
| Formula | C24H40N8O4 |
| FormulaWt. | 504.63 |
| ChemicalName | 2,2",2"",2"""-[(4,8-Di-1-piperidinylpyrimido[5,4-d]pyrimidine-2,6-diyl)dinitrilo]tetrakisethanol |
| IUPACName | 2-[[2-[bis(2-hydroxyethyl)amino]-4,8-di(piperidin-1-yl)pyrimido[5,4-d]pyrimidin-6-yl]-(2-hydroxyethyl)amino]ethanol |
| Synonym | Anginal;Cardoxin;Coridil;Dipyridan;Gulliostin;Natyl;Persantine;Piroan;Protangix |
| MeltingPoint | 163°C |
| Solubility | Solubleinmethanol,chloroformandethanol.Slightlysolubleinwater. |
| Appearance | ABrightYellowCrystallinePowder |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| MSDS | D3362MSDSPDF |
|---|---|
| InfoSheet | D3362InfoSheetPDF |
MassaroM,ScodittiE,CarluccioMA,etal.Dipyridamoledecreasesinflammatorymetalloproteinase-9expressionandreleasebyhumanmonocytes.ThrombHaemost.2013Feb;109(2):280-9.PMID:23238437.
AlbertsMJ.Antithrombotictherapyforsecondarystrokeprevention.Continuum(MinneapMinn).2011Dec;17(62ndaryStrokePrevention):1255-66.PMID:22810029.
ZhuplatovSB,MasakiT,BlumenthalDK,etal.Mechanismofdipyridamole"sactionininhibitionofvenousandarterialsmoothmusclecellproliferation.BasicClinPharmacolToxicol.2006Dec;99(6):431-9.PMID:17169124.
