Eledoisin is a tachykinin analog of substance P. Eledoisin binds neurokinin receptors, exhibiting vasodilatory and bronchoconstrictive activities. At low doses, eledoisin stimulates gastric acid secretion; at high doses, this process is inhibited. Eledoisin causes vasodilation in vivo and induces gastric contractions. Additionally, this peptide contracts smooth muscles, such as those in the bladder.
| Cas No. | 69-25-0 |
|---|---|
| Purity | ≥95% |
| Formula | C54H85N13O15S |
| Formula Wt. | 1188.44 |
| IUPAC Name | (3S)-3-[[(2S)-6-amino-2-[[(2S)-3-hydroxy-2-[[(2S)-1-[(2S)-5-oxopyrrolidine-2-carbonyl]pyrrolidine-2-carbonyl]amino]propanoyl]amino]hexanoyl]amino]-4-[[(2S)-1-[[(2S)-1-[[(2S,3S)-1-[[2-[[(2S)-1-[[(2S)-1-amino-4-methylsulfanyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-3-methyl-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1-oxopropan-2-yl]amino]-4-oxobutanoic acid |
| Appearance | White to off white powder |
| Store Temp | -20°C |
|---|---|
| Ship Temp | Ambient |
| Info Sheet | E4416 Info Sheet PDF |
|---|
Tucci P, Bolle P, Severini C. Effects of natural tachykinins on ovine lower urinary tract smooth muscle. J Auton Pharmacol. 2001 Apr;21(2):79-84. PMID: 11679016.
Ito S, Ohta T, Honda H, et al. Gastric vasodilator and motor responses to splanchnic stimulation and tachykinins in the dog. Gen Pharmacol. 1993 Mar;24(2):291-8. PMID: 7683299.
Holstein B, Cederberg C. Effects of tachykinins on gastric acid and pepsin secretion and on gastric outflow in the Atlantic cod, Gadus morhua. Am J Physiol. 1986 Mar;250(3 Pt 1):G309-15. PMID: 2420206.
