Enalaprilisanangiotensin-convertingenzyme(ACE)inhibitorthatisclinicallyusedtotreathypertension,heartfailure,anddiabeticnephropathy.Enalaprilexhibitsantihypertensiveactivity.Enalaprilpreventsandreversesrenovascularhypertension-inducedsmoothmusclehypertrophy,collagendeposition,carotidmediathicknessgrowth,andotherparametersofarterialremodeling.Additionally,enalaprilimprovesendothelialfunctioninmigrainesufferersbyincreasinglevelsofNO.
| CasNo. | 75847-73-3 |
|---|---|
| Purity | ≥98% |
| Formula | C20H28N2O5 |
| FormulaWt. | 376.45 |
| ChemicalName | N-[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]-L-alanyl-L-proline |
| IUPACName | (2S)-1-[(2S)-2-[[(2R)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]pyrrolidine-2-carboxylicacid |
| Synonym | RenitecR;VasotecR |
| MeltingPoint | 142-147°C |
| Solubility | Solubleinwater(25mg/L). |
| Appearance | WhiteCrystalPowder |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| MSDS | E5202MSDSPDF |
|---|---|
| InfoSheet | E5202InfoSheetPDF |
ChenJL,ShangQH,HuW,etal.RoleofTGF-β1/SmadspathwayincarotidarteryremodelinginrenovascularhypertensiveratsandpreventionbyEnalaprilandAmlodipine.JGeriatrCardiol.2012Jun;9(2):185-91.PMID:22916067.
BilanVP,SalahEM,BastackyS,etal.Diabeticnephropathyandlong-termtreatmenteffectsofrosiglitazoneandenalaprilinobeseZSF1rats.JEndocrinol.2011Sep;210(3):293-308.PMID:21680617.
JavanmardSH,SonbolestanSA,Heshmat-GhahdarijaniK,etal.Enalaprilimprovesendothelialfunctioninpatientswithmigraine:Arandomized,double-blind,placebo-controlledtrial.JResMedSci.2011Jan;16(1):26-32.PMID:21448379.
