Description
Eplerenonedisplaysantihypertensive,anti-inflammatory,andanti-angiogenicactivities;itinhibitsthemineralocorticoidreceptor.Eplerenoneinhibitsaldosterone-inducedexpressionofCOX(thereforedecreasingPGE2levels),preventingtheinductionofCOXandresultingkidneydamageinhighsaltdiets.Thiscompoundalsopreventssalt-inducedincreasesinNOXexpression,decreasingoxidativestressinthekidneyaswell.Inspontaneouslyhypertensiverats,eplerenoneinhibitedcardiacremodeling(hypertrophy)andleftventricledysfunction.TheantiangiogenicactivityofeplerenoneischaracterizedbyitsinhibitionofVEGFexpressioninthekidney.
References
YasuokaS,KaiH,KajimotoH,etal.BloodpressurevariABIlityactivatescardiacmineralocorticoidreceptorandinducescardiacremodelinginhypertensiverats.CircJ.2013;77(6):1474-81.PMID:23470864.
BayorhM,Rollins-HairstonA,ADIyiahJ,etal.Eplerenoneinhibitsaldosterone-inducedrenalexpressionofcyclooxygenase.JReninAngiotensinAldosteroneSyst.2012Sep;13(3):353-9.PMID:22554826.
BayorhMA,Rollins-HairstonA,AdiyiahJ,etal.Eplerenonesuppressesaldosterone/salt-inducedexpressionofNOX-4.JReninAngiotensinAldosteroneSyst.2011Sep;12(3):195-201.PMID:21292834.
EatmanD,LayasMF,BayorhMA.EplerenoneSuppressesSalt-InducedVascularEndothelialGrowthFactorExpressionintheKidney.KidneyBloodPressRes.2010Jun23;33(3):167-173.PMID:20571278.
