LKT/EXENDIN-4/E9417/2.5 mg-免疫在线蚂蚁淘旗下平台

商品详细LKT/EXENDIN-4/E9417/2.5 mg

LKT/EXENDIN-4/E9417/2.5 mg

商品编号： E9417-2.5mg

品牌： lktlabs

市场价： ¥18680.00

美元价： 11208.00

产地：美国(厂家直采)

公司：

产品分类：临床研究

公司分类： clinical_research

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

ProductIDE9417

CasNo.141758-74-9

Purity≥95%

Description
ProductInfo
ShippingandStorage
Downloads
References

Description

Exendin-4isananalogofglucagon-likepeptide1(GLP-1);itactsasanagoNISTatGLP-1receptors.Exendin-4exhibitscardioprotective,anti-inflammatory,andantioxidativeactivities.Inmesangialcells,exendin-4increasesphosphorylationofAMPKanddecreasesphosphorylationofERK,inhibitingfibronectinsecretionandcellproliferation.Inanimalmodelsofcardiacischemia/reperfusion,exendin-4decreaseslevelsofhigh-mobilitygroupbox1(HMGB1),lactatedehydrogenase(LDH),creatinekinase,andmalondialdehyde(MDA)andpreventsdecreasesinsuperoxidedismutase(SOD)levels,decreasinginfarctsize.Additionally,thiscompoundinhibitsox-LDL-inducedmigrationofmacrophages,increasesinmatrixmetalloproteinase-9(MMP9),andactivationofNF-κBinvitro.Inothercellularmodels,exendin-4suppressesincreasesinROS,activationofcaspases,andreleaseofcytochromec,preventingoxidativedamageandmitochondria-mediatedapoptosis.Exendin-4wasoriginallyfoundinHelodermalizards.LikeotherGLP-1agonists,thiscompoundmayexhibitanti-diabeticactivity.

ProductInfo

CasNo.	141758-74-9
Purity	≥95%
Formula	C₁₈₄H₂₈₂N₅₀O₆₀S
FormulaWt.	4186.03
Synonym	Exenatide,Exendin4(HelodermasUSPectum)
Appearance	Whitetooffwhitepowder

ShippingandStorage

StoreTemp	-20°C
ShipTemp	Ambient

Downloads

MSDS	E9417MSDSPDF
InfoSheet	E9417InfoSheetPDF

References

XuWW,GuanMP,ZhengZJ,etal.Exendin-4AlleviatesHighGlucose-InducedRatMesangialCellDysfunctionthroughtheAMPKPathway.CellPhysiolBiochem.2014;33(2):423-32.PMID:24556697.

HuG,ZhangY,JiangH,etal.Exendin-4attenuatesmyocardialischemiaandreperfusioninjurybyinhibitinghighmobilitygroupbox1proteinexpression.CardiolJ.2013;20(6):600-4.PMID:24338536.

MaGF,ChenS,YinL,etal.Exendin-4amelioratesoxidized-LDL-inducedinhibitionofmacrophagemigrationinvitroviatheNF-κBpathway.ActaPharmacolSin.2014Feb;35(2):195-202.PMID:24335838.

LiZ,ZhouZ,HuangG,etal.Exendin-4protectsmitochondriafromreactiveoxygenspeciesinducedapoptosisinpancreaticBetacells.PLoSOne.2013Oct24;8(10):e76172.PMID:24204601.

品牌介绍

LKT Labs LKT Labs 是一家专注于防癌抗癌特殊化学品研究和开发的公司。主要提供：癌症药物、药物发现试剂盒、天然产物、广泛的生命科学研究试剂、定制合成。美国LKT Labs 是1988年在美国成立的，为全球提供先端的药物研发试剂、试剂盒、委托合成，并为药物生产企业提供原料，最近几年在农药、水产养殖业有很大程度的开发。在LKT Labs 可以找到在其他地方找不到的产品。试剂