LKT/ROSIGLITAZONE/R5773/500 mg-免疫在线蚂蚁淘旗下平台

商品详细LKT/ROSIGLITAZONE/R5773/500 mg

LKT/ROSIGLITAZONE/R5773/500 mg

商品编号： R5773-500mg

品牌： lktlabs

市场价： ¥3640.00

美元价： 2184.00

产地：美国(厂家直采)

公司：

产品分类：临床研究

公司分类： clinical_research

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

ProductIDR5773

CasNo.122320-73-4

Purity≥98%

Description
ProductInfo
ShippingandStorage
Downloads
References

Description

RosiglitazoneisathiazolidinedioneinsulinsensitizerthatactivatesPPARγ,decreasingbloodglucoseandinsulinlevels.Rosiglitazoneexhibitsanti-diabetic,anti-inflammatory,antioxidative,anticancer,anti-angiogenic,antihypertensive,andanti-fibroticactivities.Invivo,rosiglitazonedecreasesLPS-stimulatedproductionofTNF-α,IL-1β,andIL-6aswellasactivityofmyeloperoxidase;italsoinhibitsactivationofNF-κB,preventingmastitis.Inmultiplemyelomacells,rosiglitazonesuppressesexpressionofHIF-1αandIGF-1,decreasesactivationofAky,andERK,andinhibitscellviABIlityandproliferation.Thiscompoundalsoinhibitsendothelin-1-inducedvasoconstrictioninaNO-dependentmannerinanimalmodelsofpulmonaryarterialhypertension.Additionally,rosiglitazonepreventsactivationofAP-1,productionofcollagen,anddifferentiationinfibroblasts.

ProductInfo

ShippingandStorage

CasNo.	122320-73-4
Purity	≥98%
Formula	C₁₈H₁₉N₃O₃S
FormulaWt.	357.43
ChemicalName	5-[[4-[2-(Methyl-2-pyridinylamino)ethoxy]phenyl]-methyl]-2,4-thiazolidinedione
IUPACName	5-[[4-[2-[methyl(pyridin-2-yl)amino]ethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione
Synonym	BRL-49653
MeltingPoint	153-155°C
Solubility	Solubleinethanolandinbufferedaqueoussolutions(pHof2.3).
Appearance	WhiteCrystalPowder

StoreTemp	Ambient
ShipTemp	Ambient

Downloads

MSDS	R5773MSDSPDF
InfoSheet	R5773InfoSheetPDF

References

RuiM,HuangZ,LiuY,etal.RosiglitazonesuppressesangiogenesisinmultiplemyelomaviadownregulationofhypoxiainducIBLefactor1αandinsulinlikegrowthfactor1mRNAexpression.MolMedRep.2014Jul22.[Epubaheadofprint].PMID:25050627.

MingfengD,XiaodongM,YueL,etal.EffectsofPPAR-γAgoNISTTreatmentonLPS-InducedMastitisinRats.Inflammation.2014May18.[Epubaheadofprint].PMID:24839089.

LiuY,TianXY,HuangY,etal.RosiglitazoneAttenuatedEndothelin-1-InducedVasoconstrictionofPulmonaryArteriesintheRatModelofPulmonaryArterialHypertensionviaDifferentialRegulationofET-1Receptors.PPARRes.2014;2014:374075.PMID:24701204.

HeH,TaoH,XiongH,etal.Rosiglitazonecausescardiotoxicityviaperoxisomeproliferator-activatedreceptorγ-independentmitochondrialoxidativestressinmousehearts.ToxicolSci.2014Apr;138(2):468-81.PMID:24449420.

HouX,ZhangY,ShenYH,etal.PPAR-γactivationbyrosiglitazonesuppressesangiotensinII-mediatedproliferationandphenotypictransitionincardiacfibroblastsviainhibitionofactivationofactivatorprotein1.EurJPharmacol.2013Sep5;715(1-3):196-203.PMID:23791613.

品牌介绍

LKT Labs LKT Labs 是一家专注于防癌抗癌特殊化学品研究和开发的公司。主要提供：癌症药物、药物发现试剂盒、天然产物、广泛的生命科学研究试剂、定制合成。美国LKT Labs 是1988年在美国成立的，为全球提供先端的药物研发试剂、试剂盒、委托合成，并为药物生产企业提供原料，最近几年在农药、水产养殖业有很大程度的开发。在LKT Labs 可以找到在其他地方找不到的产品。试剂