LKT/ROXITHROMYCIN/R5992/1 g-免疫在线蚂蚁淘旗下平台

商品详细LKT/ROXITHROMYCIN/R5992/1 g

LKT/ROXITHROMYCIN/R5992/1 g

商品编号： R5992-1g

品牌： lktlabs

市场价： ¥600.00

美元价： 360.00

产地：美国(厂家直采)

公司：

产品分类：临床研究

公司分类： clinical_research

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

ProductIDR5992

CasNo.80214-83-1

Purity≥96%

Description
ProductInfo
ShippingandStorage
Downloads
References

Description

Roxithromycinisasemi-syntheticmacrolideantibioticthatexhibitsanti-inflammatory,anti-asthma,vasodilatory,antibacterial,andanti-arthriticactivities;itbindstothe50Sribosome,inhibitingproteinsynthesis.Inanimalmodelsofovalbumin-inducedasthma,roxithromycindecreasesthenumberofinflammatorycellsandairwayhyperresponsivenessandsuppresseslevelsofIgE,inflammatorycytokines,andactivatedNF-κB.Roxithromycinalsoinducesvascularrelaxationexvivoinarteriesandthoracicaortasegments.Inmacrophages,thiscompoundinhibitsTcellproductionofTNF-αandIL-6;inanimalmodelsofarthritis,itinhibitsTcellmigrationanddecreasesdiseaseseverity.

ProductInfo

CasNo.	80214-83-1
Purity	≥96%
Formula	C₄₁H₇₆N₂O₁₅
FormulaWt.	837.05
ChemicalName	Erythromycin9-[-O-[(2-methoxyethoxy)methyl]-oxime]
IUPACName	(3R,4S,5S,6R,7R,9R,10Z,11S,12R,13S,14R)-6-[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-14-ethyl-7,12,13-trihydroxy-4-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-10-(2-methoxyethoxymethoxyimino)-3,5,7,9,11,13-hexamethyl-oxacyclotetradecan-2-one
Synonym	Rulide;Surlid;Rotramin;Claramid;Overal;Rossitrol
MeltingPoint	115-120°C
Solubility	SolubleinHCl,andNaOH.Slightlysolubleinalcoholandwater.
Appearance	Whiteoroff-whitecrystalpowder

ShippingandStorage

StoreTemp	4°C
ShipTemp	Ambient

Downloads

MSDS	R5992MSDSPDF
InfoSheet	R5992InfoSheetPDF

References

CiX,ChuX,XuX,etal.Short-termroxithromycintreatmentattenuatesairwayinflammationviaMAPK/NF-κBactivationinamousemodelofallergicasthma.InflammRes.2012Jul;61(7):749-58.PMID:22481373.

BiavaM,PorrettaGC,DeiddaD,etal.Newtrendsindevelopmentofantimycobacterialcompounds.InfectDisordDrugTargets.2006Jun;6(2):159-72.PMID:16789877.

UrasakiY,NoriM,IwataS,etal.RoxithromycinspecificallyinhibitsdevelopmentofcollageninducedarthritisandproductionofproinflammatorycytokinesbyhumanTcellsandmacrophages.JRheumatol.2005Sep;32(9):1765-74.PMID:16142877.

BermanM,HasdaiD,RaananiE,etal.Ex-vivoeffectofroxithromycinonhumanandratarterialvasoactivity.InteractCardiovascThoracSurg.2005Jun;4(3):232-7.PMID:17670399.

品牌介绍

LKT Labs LKT Labs 是一家专注于防癌抗癌特殊化学品研究和开发的公司。主要提供：癌症药物、药物发现试剂盒、天然产物、广泛的生命科学研究试剂、定制合成。美国LKT Labs 是1988年在美国成立的，为全球提供先端的药物研发试剂、试剂盒、委托合成，并为药物生产企业提供原料，最近几年在农药、水产养殖业有很大程度的开发。在LKT Labs 可以找到在其他地方找不到的产品。试剂