LKT/合成吴茱萸次碱/R8179/250 mg-免疫在线蚂蚁淘旗下平台

商品详细LKT/合成吴茱萸次碱/R8179/250 mg

LKT/合成吴茱萸次碱/R8179/250 mg

商品编号： R8179-250mg

品牌： lktlabs

市场价： ¥5980.00

美元价： 3588.00

产地：美国(厂家直采)

公司：

产品分类：临床研究

公司分类： clinical_research

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

立即询价

商品介绍

ProductIDR8179

CasNo.84-26-4

Purity≥98%

Description
ProductInfo
ShippingandStorage
Downloads
References

Description

RutaecarpineisanindoloquinazolinealkaloidoriginallyfoundinEvodia;itexhibitsanti-inflammatory,anti-atherosclerotic,cardioprotective,anorexigenic,andanti-obesityactivities.RutaecarpineinhibitsCOX-2andalsodecreasesfoodintake,weightgain,andserumglucose,leptin,andinsulinlevelsinvivobyinhibitingexpressionofneuropeptideYandAgRP.Rutaecarpinealsoinhibitsaccumulationofmacrophagesandcholesterolinatheroscleroticlesionsandincreasescholesterolexcretioninotheranimalmodels.Additionally,rutaecarpineinhibitshypoxia-inducedproductionofROSandlactatedehydrogenaseandsuppressesapoptosisinmyocardiocytes.Inothercellularmodels,rutaecarpinedecreasescorticosteroneproduction,potentiallythroughinhibitionofcAMP,3β-hydroxysteroiddehydrogenase,and11β-hydroxylaseactivity.RutaecarpinealsoinhibitsproductionofROS,NO,andiNOS,potentiallythroughinhibitionofNADPHoxidase.Inmacrophages,rutaecarpineinhibitsarachidonicacidreleaseanddecreasesproductionofprostaglandinE2(PGE2);inotherinvitromodels,itinhibitscollagen-stimulatedformationofthromboxaneB2andinosinemonophosphate.

ProductInfo

ShippingandStorage

CasNo.	84-26-4
Purity	≥98%
Formula	C₁₈H₁₃N₃O
FormulaWt.	287.32
ChemicalName	8,13-Dihydroindolo[2",3":3,4]pyrido[2,1-b]quinazolin-5(7H)-one
Synonym	Rutecarpine
MeltingPoint	259.5-260°C
Solubility	Solubleinalcohol,benzene,chloroformandether.Practicallyinsolubleinwater.
Appearance	Greywhitepowder

StoreTemp	4°C
ShipTemp	Ambient

Downloads

InfoSheet	R8179InfoSheetPDF

References

XuY,LiuQ,XuY,etal.RutaecarpinesuppressesatherosclerosisinApoE-/-micethroughup-regulatingABCA1andSR-BIwithinRCT.JLipidRes.2014Jun7.[Epubaheadofprint].PMID:24908654.

ChenYC,ZengXY,HeY,etal.RutaecarpineanaloguesreducelipidaccumulationinADIpocytesviainhibitingAdipogenesis/lipogenesiswithAMPKactivationandUPRsuppression.ACSChemBiol.2013Oct18;8(10):2301-11.PMID:23962138.

BaoMH,DaiW,LiYJ,etal.Rutaecarpinepreventshypoxia-reoxygenation-inducedmyocardialcellapoptosisviainhibitionofNADPHoxidases.CanJPhysiolPharmacol.2011Mar;89(3):177-86.PMID:21423291.

KimSJ,LeeSJ,LeeS,etal.RutecarpineamelioratesbodyweightgainthroughtheinhibitionoforexigenicneuropeptidesNPYandAgRPinmice.BiochemBiophysResCommun.2009Nov20;389(3):437-42.PMID:19732749.

YuPL,ChaoHL,WangSW,etal.Effectsofevodiamineandrutaecarpineonthesecretionofcorticosteronebyzonafasciculata-reticulariscellsinmalerats.JCellBiochem.2009Oct1;108(2):469-75.PMID:19639602.

SheuJR,HungWC,LeeYM,etal.Mechanismofinhibitionofplateletaggregationbyrutaecarpine,analkaloidisolatedfromEvodiarutaecarpa.EurJPharmacol.1996Dec30;318(2-3):469-75.PMID:9016940.

品牌介绍

LKT Labs LKT Labs 是一家专注于防癌抗癌特殊化学品研究和开发的公司。主要提供：癌症药物、药物发现试剂盒、天然产物、广泛的生命科学研究试剂、定制合成。美国LKT Labs 是1988年在美国成立的，为全球提供先端的药物研发试剂、试剂盒、委托合成，并为药物生产企业提供原料，最近几年在农药、水产养殖业有很大程度的开发。在LKT Labs 可以找到在其他地方找不到的产品。试剂