LKT/S-NITROSOGLUTATHIONE/N3378/10 mg-免疫在线蚂蚁淘旗下平台

商品详细LKT/S-NITROSOGLUTATHIONE/N3378/10 mg

LKT/S-NITROSOGLUTATHIONE/N3378/10 mg

商品编号： N3378-10mg

品牌： lktlabs

市场价： ¥3500.00

美元价： 2100.00

产地：美国(厂家直采)

公司：

产品分类：临床研究

公司分类： clinical_research

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

ProductIDN3378

CasNo.57564-91-7

Purity≥98%

Description
ProductInfo
ShippingandStorage
Downloads
References

Description

S-NitroglutathioneactsasaNOdonor,displayingantioxidative,bronchodilatory,vasodilatory,andanticanceractivities.Inthevasculature,S-nitroglutathioneattenuatesPannexin-1channelcurrentsandATPrelease.Inepithelialcellsfromcysticfibrosispatients,S-nitroglutathionepromotesmaturationofthedefectiveCFtransmembraneconductanceregulator(CFTR),increasingcAMP-inducedCl-effluxandimprovingdefectiveCl-transport.DonationofNOtoactinresultsinlesseffectivepolymerizationbutproducesavasodilatoryeffect.Additionally,donationofNOtoproteinsinvolvedininsulinsignaltransductionimprovesinsulinresistance.S-NitroglutathionealsostimulatesactivationofERK1/2andp38,inducingNO-relatedapoptosisincoloncancercells;inthismodel,glutathioneandsuperoxidedismutasearelikelytoplayaroleaswell.

ProductInfo

CasNo.	57564-91-7
Purity	≥98%
Formula	C₁₀H₁₆N₄O₇S
FormulaWt.	336.32
IUPACName	(2S)-2-amino-5-[[(2R)-1-(carboxymethylamino)-3-nitrososulfanyl-1-oxopropan-2-yl]amino]-5-oxopentanoicacid
MeltingPoint	185-195°C
Appearance	Pinkpowder

ShippingandStorage

StoreTemp	-20°C
ShipTemp	Ambient

Downloads

InfoSheet	N3378InfoSheetPDF

References

LohmanAW,WeaverJL,BillaudM,etal.S-nitrosylationinhibitspannexin1channelfunction.JBiolChem.2012Nov16;287(47):39602-12.PMID:23033481.

ServetnykZ,KrjukovaJ,GastonB,etal.ActivationofchloridetransportinCFairwayepithelialcelllinesandprimaryCFnasalepithelialcellsbyS-nitrosoglutathione.RespirRes.2006Oct5;7:124.PMID:17022806.

Carvalho-FilhoMA,UenoM,HirabaraSM,etal.S-nitrosationoftheinsulinreceptor,insulinreceptorsubstrate1,andproteinkinaseB/Akt:anovelmechanismofinsulinresistance.Diabetes.2005Apr;54(4):959-67.PMID:15793233.

JeonHK,ChoiSU,JungNP.AssociationoftheERK1/2andp38kinasepathwayswithnitricoxide-inducedapoptosisandcellcyclearrestincoloncancercells.CellBiolToxicol.2005Mar;21(2):115-25.PMID:16142585.

CirioloMR,AquilanoK,DeMartinoA,etal.DifferentialroleofsuperoxideandglutathioneinS-nitrosoglutathione-mediatedapoptosis:arationaleformildformsoffamilialamyotrophiclateralsclerosisassociatedwithlessactiveCu,Znsuperoxidedismutasemutants.JNeuRochem.2001Jun;77(6):1433-43.PMID:11413228.

Dalle-DonneI,MilzaniA,GiustariniD,etal.S-NO-actin:S-nitrosylationkineticsandtheeffectonisolatedvascularsmoothmuscle.JMuscleResCellMotil.2000Feb;21(2):171-81.PMID:10961840.

MessmerUK,BrüneB.Nitricoxide-inducedapoptosis:p53-dependentandp53-independentsignallingpathways.BiochemJ.1996Oct1;319(Pt1):299-305.PMID:8870682.

品牌介绍

LKT Labs LKT Labs 是一家专注于防癌抗癌特殊化学品研究和开发的公司。主要提供：癌症药物、药物发现试剂盒、天然产物、广泛的生命科学研究试剂、定制合成。美国LKT Labs 是1988年在美国成立的，为全球提供先端的药物研发试剂、试剂盒、委托合成，并为药物生产企业提供原料，最近几年在农药、水产养殖业有很大程度的开发。在LKT Labs 可以找到在其他地方找不到的产品。试剂