Sauvagineisacorticotropin-releasingfactor(CRF)-familypeptidefoundinamphibians;itexhibitsdiuretic,vasodilatory,andneuromodulatoryactivitiesandisinvolvedingrowth,stress,anxiety,andmanyotherhormonalsignalingpathways.Sauvagineinducesvasodilationinratthoracicaortas,potentiallythroughprolongedactivationofNOS.Additionally,sauvagineincreasesstriataltyrosinehydroxylaseactivityinaCa2+-dependentmanner.
| CasNo. | 74434-59-6 |
|---|---|
| Purity | ≥98% |
| Formula | C202H347N56O63S |
| FormulaWt. | 4599.4 |
| Synonym | Sauvagin |
| Solubility | Solubleinwater. |
| Appearance | Whitetooffwhitepowder |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | S0381InfoSheetPDF |
|---|
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BarkerDM,CorderR.Studiesoftheroleofendothelium-dependentnitricoxidereleaseinthesustainedvasodilatoreffectsofcorticotrophinreleasingfactorandsauvagine.BrJPharmacol.1999Jan;126(1):317-25.PMID:10051151.
OnaliP,OlianasMC.CRF-likeeffectsofsauvagineandurotensinIonsynaptosomaltyrosinehydroxylaseactivityofmousestriatum.BrainRes.1990Sep3;526(2):181-5.PMID:1979515.
