Description
SFLLR is a peptide agonist of protease-activated receptor type 1 (PAR1, also known as the thrombin receptor) that induces platelet adhesion and aggregation, mimicking the effects of thrombin. SFLLR exhibits pro-thrombotic, pro-angiogenic, and pro-inflammatory activities. In vagal motor neurons, SFLLR induces apoptosis. SFLLR increases release of pro-matrix metalloproteinase 9 (pro-MMP9) from fibroblasts in a JAK/STAT3-dependent manner; it also increases expression of matrix metalloproteinase 2 (MMP2) and induces angiogenesis in endothelial cells. SFLLR increases release of IL-6 from T cells as well. Additionally, this peptide can increase Na+ current in cardiomyocytes.
References
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Wang L, Luo J, He S. Induction of MMP-9 release from human dermal fibroblasts by thrombin: involvement of JAK/STAT3 signaling pathway in MMP-9 release. BMC Cell Biol. 2007 May 7;8:14. PMID: 17480240.
Li T, He S. Induction of IL-6 release from human T cells by PAR-1 and PAR-2 agonists. Immunol Cell Biol. 2006 Oct;84(5):461-6. PMID: 16869943.
Maragoudakis ME, Kraniti N, Giannopoulou E, et al. Modulation of angiogenesis and progelatinase a by thrombin receptor mimetics and antagonists. Endothelium. 2001;8(3):195-205. PMID: 11824472.
Sabo T, Gurwitz D, Motola L, et al. Structure-activity studies of the thrombin receptor activating peptide. Biochem Biophys Res Commun. 1992 Oct 30;188(2):604-10. PMID: 1332704.
