NigericinisanantibioticfoundinStreptomycesthatexhibitsantibacterialactivityagainstgrampositivebacteria.NigericininhibitsGolgifunctionandviralactivation,actingasanantiviralcompound.NigericinalsoactsasaH+/K+/Pb2+ionophore.Additionally,thiscompounddisplayspro-inflammatoryandimmunostimulatoryactivities,triggeringactivationoftheNALP3inflammasome.
| CasNo. | 28643-80-3 |
|---|---|
| Purity | ≥98% |
| Formula | C40H67O11Na |
| FormulaWt. | 746.94 |
| ChemicalName | AntibioticK178Sodiumsalt |
| IUPACName | sodium;2-[(3S,6R)-6-[[(5R,6R,7R,9R)-2-[5-[(3S,5R)-5-[(2S,3S,5R,6R)-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyloxan-2-yl]-3-methyloxolan-2-yl]-5-methyloxolan-2-yl]-7-methoxy-2,4,6-trimethyl-1,10-dioxaspiro[4.5]decan-9-yl]methyl]-3-methyloxan-2-yl]propanoate |
| Synonym | AzalomycinM;HelixinC;PolyetherinA. |
| MeltingPoint | 245-255°C |
| Solubility | Solubleinchloroform.Practicallyinsolubleinwater. |
| Appearance | Whitepowder |
| StoreTemp | 4°C |
|---|---|
| ShipTemp | Ambient |
| MSDS | N3225MSDSPDF |
|---|---|
| InfoSheet | N3225InfoSheetPDF |
HeidME,KeyelPA,KamgaC,etal.MitochondrialreactiveoxygenspeciesinducesNLRP3-dependentlysosomaldamageandinflammasomeactivation.JImmunol.2013Nov15;191(10):5230-8.PMID:24089192.
MyskiwC,PiperJ,HuzarewichR,etal.Nigericinisapotentinhibitoroftheearlystageofvacciniavirusreplication.AntiviralRes.2010Dec;88(3):304-10.PMID:20951746.
