Nigericin is an antibiotic found in Streptomyces that exhibits antibacterial activity against gram positive bacteria. Nigericin inhibits Golgi function and viral activation, acting as an antiviral compound. Nigericin also acts as a H+/K+/Pb2+ ionophore. Additionally, this compound displays pro-inflammatory and immunostimulatory activities, triggering activation of the NALP3 inflammasome.
| Cas No. | 28643-80-3 |
|---|---|
| Purity | ≥98% |
| Formula | C40H67O11Na |
| Formula Wt. | 746.94 |
| Chemical Name | Antibiotic K 178 Sodium salt |
| IUPAC Name | sodium;2-[(3S,6R)-6-[[(5R,6R,7R,9R)-2-[5-[(3S,5R)-5-[(2S,3S,5R,6R)-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyloxan-2-yl]-3-methyloxolan-2-yl]-5-methyloxolan-2-yl]-7-methoxy-2,4,6-trimethyl-1,10-dioxaspiro[4.5]decan-9-yl]methyl]-3-methyloxan-2-yl]propanoate |
| Synonym | Azalomycin M; Helixin C; Polyetherin A. |
| Melting Point | 245-255°C |
| Solubility | Soluble in chloroform. Practically insoluble in water. |
| Appearance | White powder |
| Store Temp | 4°C |
|---|---|
| Ship Temp | Ambient |
| MSDS | N3225 MSDS PDF |
|---|---|
| Info Sheet | N3225 Info Sheet PDF |
Heid ME, Keyel PA, Kamga C, et al. Mitochondrial reactive oxygen species induces NLRP3-dependent lysosomal damage and inflammasome activation. J Immunol. 2013 Nov 15;191(10):5230-8. PMID: 24089192.
Myskiw C, Piper J, Huzarewich R, et al. Nigericin is a potent inhibitor of the early stage of vaccinia virus replication. Antiviral Res. 2010 Dec;88(3):304-10. PMID: 20951746.
