LKT/NORDIHYDROGUAIARETIC ACID/N5669/500 mg-免疫在线蚂蚁淘旗下平台

商品详细LKT/NORDIHYDROGUAIARETIC ACID/N5669/500 mg

LKT/NORDIHYDROGUAIARETIC ACID/N5669/500 mg

商品编号： N5669-500mg

品牌： lktlabs

市场价： ¥880.00

美元价： 528.00

产地：美国(厂家直采)

公司：

产品分类：临床研究

公司分类： clinical_research

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

ProductIDN5669

CasNo.500-38-9

Purity≥97%

Description
ProductInfo
ShippingandStorage
Downloads
References

Description

Nordihydroguaiareticacid(NDGA)isaphenolfoundinthecreosotebushthatexhibitsantioxidative,antiviral,anti-angiogenic,anti-metastatic,anti-inflammatory,anti-hyperlipidemic,anti-osteoporotic,anti-aging,neuromodulatory,anti-parasitic,antifungal,andanticancerchemotherapeuticactivities.NDGAscavengesROS,inhibits5-lipoxygenase,andactivatesNrf2.Thiscompoundinhibitsdenguevirusreplicationbypreventingviralassembly;italsoinhibitsgrowthofCulexandCandida.Inanimalmodels,NDGAincreasesoveralllifespanandinhibitsacetylcholinesterase(AChE)andbutylcholinesterase(BChE).Invivo,NDGAinhibitsangiogenesisandsuppressesinvasionandproliferationofgliomacells.Invariousmodels,NDGAinhibitsCa2+signalingandPAR2activity,decreasingexpressionofIL-8,ICAM-1,IgE,andinvolucrin.Inanimalmodels,thiscompoundincreasesexpressionofPPARαanddecreaseslevelsofserumtriglyceridesandliverweight.Additionally,NDGAinhibitsosteoclastogenesisinvitroanddecreasesbonedestructioninvivo.Incellularandanimalmodelsofbreastcancer,NDGAinhibitsmTORC1,decreasesexpressionofVEGF,cyclinD1,andHIF-1α,andsuppressescellularproliferationandtumorgrowth.

ProductInfo

CasNo.	500-38-9
Purity	≥97%
Formula	C₁₈H₂₂O₄
FormulaWt.	302.36
ChemicalName	4,4-(2,3-Dimethyl-1,4butanediyl)bis[1,2-benzenediol]
IUPACName	4-[4-(3,4-dihydroxyphenyl)-2,3-dimethylbutyl]benzene-1,2-diol
Synonym	NDGA;Dihydronorguaiareticacid;Pyrocatechol,4,4"-(2,3-dimethyltetramethylene)di-
MeltingPoint	184-186°C
Solubility	Solubleinethanol,methanol,orhotwater.
Appearance	WhiteSolidCrystalline

ShippingandStorage

StoreTemp	Ambient
ShipTemp	Ambient

Downloads

InfoSheet	N5669InfoSheetPDF

References

Hernández-DamiánJ,Andérica-RomeroAC,Pedraza-ChaverriJ.ParadoxicalcellulareffectsandBIOLOGicalroleofthemultifacetedcompoundnordihydroguaiareticAcid.ArchPharm(Weinheim).2014Oct;347(10):685-97.PMID:25100573.

Soto-AcostaR,Bautista-CarbajalP,SyedGH,etal.Nordihydroguaiareticacid(NDGA)inhibitsreplicationandviralmorphogenesisofdenguevirus.AntiviralRes.2014Sep;109:132-40.PMID:25017471.

HarrisonDE,StrongR,AllisonDB,etal.Acarbose,17-α-estrADIol,andnordihydroguaiareticacidextendmouseLifespanpreferentiallyinmales.AgingCell.2014Apr;13(2):273-82.PMID:24245565.

YangX,CuiW,YuS,etal.Asyntheticdl-nordihydroguaiareticacid(Nordy),inhibitsangiogenesis,invasionandproliferationofgliomastemcellswithinazebrafishxenotransplantationmodel.PLoSOne.2014Jan15;9(1):e85759.PMID:24454929.

SzwajgierD.Anticholinesteraseactivityofphenolicacidsandtheirderivatives.ZNaturforschC.2013Mar-Apr;68(3-4):125-32.PMID:23819308.

BatallánG,TorreR,FloresF,etal.LarvicidalactivityofcrudeextractsfromLarreacuneifolia(Zygophyllaceae)andofitsmetabolitenordihydroguaiareticacidagainstthevectorCulexquinquefasciatus(Diptera:Culicidae).RevSocBrasMedTrop.2013Jan-Feb;46(1):84-7.PMID:23563831.

ZhangH,ShenWJ,CortezY,etal.NordihydroguaiareticacidimprovesmetabolicdysregulationandaberranthepaticlipidmetabolisminmicebybothPPARα-dependentand-independentpathways.AmJPhysiolGastrointestLiverPhysiol.2013Jan1;304(1):G72-86.PMID:23104557.

MartinoRF,DavicinoRC,MattarMA,etal.Macrophagesactivationbyapurifiedfraction,freeofnordihydroguaiareticacid(NDGA),fromLarreadivaricataCav.asapotentialnoveltherapyagainstCandidaalbicans.ImmunopharmacolImmunotoxicol.2012Dec;34(6):975-82.PMID:22551492.

LiYJ,KukitaA,WatanabeT,etal.NordihydroguaiareticacidinhibitionofNFATc1suppressesosteoclastogenesisandarthritisbonedestructioninrats.LabInvest.2012Dec;92(12):1777-87.PMID:23044922.

ZhangY,XuS,LinJ,etal.mTORC1isatargetofnordihydroguaiareticacidtopreventbreasttumorgrowthinvitroandinvivo.BreastCancerResTreat.2012Nov;136(2):379-88.PMID:23053656.

KimHY,GooJH,JooYA,etal.ImpactoninflammationandrecoveryofskinbarrierbynordihydroguaiareticAcidasaprotease-activatedreceptor2antagoNIST.BiomolTher(Seoul).2012Sep;20(5):463-9.PMID:24009835.

品牌介绍

LKT Labs LKT Labs 是一家专注于防癌抗癌特殊化学品研究和开发的公司。主要提供：癌症药物、药物发现试剂盒、天然产物、广泛的生命科学研究试剂、定制合成。美国LKT Labs 是1988年在美国成立的，为全球提供先端的药物研发试剂、试剂盒、委托合成，并为药物生产企业提供原料，最近几年在农药、水产养殖业有很大程度的开发。在LKT Labs 可以找到在其他地方找不到的产品。试剂