Description
NotoginsenosideR1isatriterpenesaponinoriginallyfoundinspeciesofPanax(ginseng)thatexhibitsneuroprotective,anti-atherosclerotic,anti-inflammatory,anti-hyperlipidemic,andimmunostimulatoryactivities.NotoginsenosideR1decreasesamyloid-β-inducedoxidativedamageandMAPKsignaling,improvingcellviABIlityincellularmodelsofAlzheimer’sdisease.InApoEknockoutanimals,notoginsenosideR1increasesexpressionofglutathioneandsuperoxidedismutaseanddecreasesexpressionofinflammatorycytokines;italsodecreasesLDL,triglyceride,andcholesterollevelsandincreasesHDLlevels,preventingatheroscleroticlesions.Thiscompoundalsoincreasesantigen-inducedspleenocyteproliferationandIgGtitersinvivo.