LKT/OLMESARTAN MEDOXOMIL/O4549/250 mg-免疫在线蚂蚁淘旗下平台

商品详细LKT/OLMESARTAN MEDOXOMIL/O4549/250 mg

LKT/OLMESARTAN MEDOXOMIL/O4549/250 mg

商品编号： O4549-250mg

品牌： lktlabs

市场价： ¥5240.00

美元价： 3144.00

产地：美国(厂家直采)

公司：

产品分类：临床研究

公司分类： clinical_research

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

立即询价

商品介绍

ProductIDO4549

CasNo.144689-63-4

Purity≥98%

Description
ProductInfo
ShippingandStorage
Downloads
References

Description

OlmesartanmedoxomilisanangiotensinIItype1receptor(AT1)inhibitorthatinhibitsnegativeregulatoryfeedbackonreninsecretion,decreasingsecretionofaldosteroneandresultingindecreasedperipheralvascularresistance(vasodilation).Thiscompoundexhibitsantihypertensive,cardioprotective,vasodilatory,andanti-inflammatoryactivities.Duetothisaction,olmesartanincreasescerebralbloodflowandcerebrovascularreservecapacityinhypertensivestrokepatients.Additionally,thiscompoundimprovescardiacfunctionthroughactivationoftheDLL4/Notch1signalingpathwayinanimalmodelsofchroniccardiacpressureoverload.Olmesartanalsoinhibitsactivationofapoptosissignalregulatingkinase1(ASK1)inanimalmodelsofdiabetes,attenuatingcardiacinflammationandvascularendothelialdysfunction.

ProductInfo

CasNo.	144689-63-4
Purity	≥98%
Formula	C₂₉H₃₀N₆O₆
FormulaWt.	558.59
ChemicalName	(5-methyl-2-oxo-2H-1,3-dioxol-4-yl)methyl4-(2-hydroxypropan-2-yl)-2-propyl-1-({4-[2-(2H-1,2,3,4-tetrazol-5-yl)phenyl]phenyl}methyl)-1H-imidazole-5-carboxylate
IUPACName	(5-methyl-2-oxo-1,3-dioxol-4-yl)methyl5-(2-hydroxypropan-2-yl)-2-propyl-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]imidazole-4-carboxylate
Appearance	Whitetooffwhitepowder

ShippingandStorage

StoreTemp	Ambient
ShipTemp	Ambient

Downloads

MSDS	O4549MSDSPDF
InfoSheet	O4549InfoSheetPDF

References

YouJ,WuJ,JiangG,etal.OlmesartanattenuatescardiacremodelingthroughDLL4/Notch1pathwayactivationinpressureoverloadmice.JCardiovascPharmacol.2013Feb;61(2):142-51.PMID:23188126.

VerdecchiaP,AngeliF,RepaciS,etal.Comparativeassessmentofangiotensinreceptorblockersindifferentclinicalsettings.VascHealthRiskManag.2009;5:939-48.PMID:19997575.

MatsumotoS,ShimodozonoM,MiyataR,etal.BenefitsoftheangiotensinIIreceptorantagoNISTolmesartanincontrollinghypertensionandcerebralhemodynamicsafterstroke.HypertensRes.2009Nov;32(11):1015-21.PMID:19745828.

YamamotoE,DongYF,KataokaK,etal.Olmesartanpreventscardiovascularinjuryandhepaticsteatosisinobesityanddiabetes,accompaniedbyapoptosissignalregulatingkinase-1inhibition.Hypertension.2008Sep;52(3):573-80.PMID:18678790.

BrousilJA,BurkeJM.Olmesartanmedoxomil:anangiotensinII-receptorblocker.ClinTher.2003Apr;25(4):1041-55.PMID:12809956.

品牌介绍

LKT Labs LKT Labs 是一家专注于防癌抗癌特殊化学品研究和开发的公司。主要提供：癌症药物、药物发现试剂盒、天然产物、广泛的生命科学研究试剂、定制合成。美国LKT Labs 是1988年在美国成立的，为全球提供先端的药物研发试剂、试剂盒、委托合成，并为药物生产企业提供原料，最近几年在农药、水产养殖业有很大程度的开发。在LKT Labs 可以找到在其他地方找不到的产品。试剂