Description
Osthole is an O-methylated coumarin that inhibits Ca2+ channels. It exhibits anticancer, antioxidative, anti-inflammatory, and cardioprotective activities. In glioblastoma cells, osthole inhibits IGF-1-induced epithelial-to-mesenchymal transition (EMT), decreases phosphorylation of Akt and GSK-3β, inhibiting cell migration. Osthole also exhibits anti-metastatic potential in lung cancer cells, inhibiting migration and invasion by decreasing expression of matrix metalloproteinases 2 and 9 (MMP2/9). In animal models of ischemia/reperfusion, osthole decreases levels of ROS, malondialdehyde, IL-6, TNF-α, and myeloperoxidase, increases activity of superoxide dismutase, and improves lung injury pathology. Osthole also inhibits lung inflammation induced by administration of carrageenan in vivo. In animal models of cardiac ischemia/reperfusion, this compound inhibits lipid peroxidation and decreases expression of HMGB1 and NF-κB.
References
Lin YC, Lin JC, Hung CM, et al. Osthole inhibits insulin-like growth factor-1-induced epithelial to mesenchymal transition via the inhibition of PI3K/Akt signaling pathway in human brain cancer cells. J Agric Food Chem. 2014 May 14. [Epub ahead of print]. PMID: 24828835.
Li Z, Ji H, Song X, et al. Osthole attenuates the development of carrageenan-induced lung inflammation in rats. Int Immunopharmacol. 2014 May;20(1):33-6. PMID: 24576740.
Mo LQ, Chen Y, Song L, et al. Osthole prevents intestinal ischemia-reperfusion-induced lung injury in a rodent model. J Surg Res. 2014 Mar 15. [Epub ahead of print]. PMID: 24726060.
Wang XY, Dong WP, Bi SH, et al. Protective effects of osthole against myocardial ischemia/reperfusion injury in rats. Int J Mol Med. 2013 Aug;32(2):365-72. PMID: 23695269.
Xu XM, Zhang Y, Qu D, et al. Osthole suppresses migration and invasion of A549 human lung cancer cells through inhibition of matrix metalloproteinase-2 and matrix metallopeptidase-9 in vitro. Mol Med Rep. 2012 Nov;6(5):1018-22. PMID: 22923177.
