Description
OstholeisanO-methylatedcoumarinthatinhibitsCa2+channels.Itexhibitsanticancer,antioxidative,anti-inflammatory,andcardioprotectiveactivities.Inglioblastomacells,ostholeinhibitsIGF-1-inducedepithelial-to-mesenchymaltransition(EMT),decreasesphosphorylationofAktandGSK-3β,inhibitingcellmigration.Ostholealsoexhibitsanti-metastaticpotentialinlungcancercells,inhibitingmigrationandinvasionbydecreasingexpressionofmatrixmetalloproteinases2and9(MMP2/9).Inanimalmodelsofischemia/reperfusion,ostholedecreaseslevelsofROS,malondialdehyde,IL-6,TNF-α,andmyeloperoxidase,increasesactivityofsuperoxidedismutase,andimproveslunginjurypathology.OstholealsoinhibitslunginflammationinducedbyadmiNISTrationofcarrageenaninvivo.Inanimalmodelsofcardiacischemia/reperfusion,thiscompoundinhibitslipidperoxidationanddecreasesexpressionofHMGB1andNF-κB.
References
LinYC,LinJC,HungCM,etal.Ostholeinhibitsinsulin-likegrowthfactor-1-inducedepithelialtomesenchymaltransitionviatheinhibitionofPI3K/Aktsignalingpathwayinhumanbraincancercells.JAgricFoodChem.2014May14.[Epubaheadofprint].PMID:24828835.
LiZ,JiH,SongX,etal.Ostholeattenuatesthedevelopmentofcarrageenan-inducedlunginflammationinrats.IntImmunopharmacol.2014May;20(1):33-6.PMID:24576740.
MoLQ,ChenY,SongL,etal.Ostholepreventsintestinalischemia-reperfusion-inducedlunginjuryinarodentmodel.JSurgRes.2014Mar15.[Epubaheadofprint].PMID:24726060.
WangXY,DongWP,BiSH,etal.Protectiveeffectsofostholeagainstmyocardialischemia/reperfusioninjuryinrats.IntJMolMed.2013Aug;32(2):365-72.PMID:23695269.
XuXM,ZhangY,QuD,etal.OstholesuppressesmigrationandinvasionofA549humanlungcancercellsthroughinhibitionofmatrixmetalloproteinase-2andmatrixmetallopeptidase-9invitro.MolMedRep.2012Nov;6(5):1018-22.PMID:22923177.
