LKT/PAEONOL/P0219/1 g-免疫在线蚂蚁淘旗下平台

商品详细LKT/PAEONOL/P0219/1 g

LKT/PAEONOL/P0219/1 g

商品编号： P0219-1g

品牌： lktlabs

市场价： ¥600.00

美元价： 360.00

产地：美国(厂家直采)

公司：

产品分类：临床研究

公司分类： clinical_research

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

ProductIDP0219

CasNo.552-41-0

Purity≥98%

Description
ProductInfo
ShippingandStorage
Downloads
References

Description

PaeonolwasoriginallyfoundinspeciesofPaeonia,Arisaema,andDioscorea.Paeonolexhibitsanti-inflammatory,analgesic,neuromodulatory,vasodilatory,anticancer,anti-atherosclerotic,andanti-angiogenicactivities.Paeonolinhibitscarrageenan-inducedthermalhyperalgesiaanddecreasesproductionofTNF-α,IL-1β,COX-2,andiNOS.Paeonolalsoinducesrelaxationinaorticrings,potentiallythroughinhibitionofvoltage-gatedandreceptor-gatedCa2+channels.Inovariancancercells,paeonoldecreasesviABIlitybyincreasingactivationofcaspase3,downregulatingexpressionofsurvivin,andinducingapoptosis.Thiscompoundalsodecreasesexpressionofmatrixmetalloproteinases2and9(MMP2/9),suppressesactivationofAkt,andpreventsmigration,tubeformation,andvesselformationinvivoandinvitro.Additionally,paeonoldecreasesreleaseoflactatedehydrogenase,expressionofVCAM-1,andactivationofJNK1/2,ERK1/2,andp38MAPK,preventingmonocyteadhesiontovascularendothelialcells.PaeonolalsoinhibitsmonoamineoxidasesAandB(MAO-A,MAO-B).

ProductInfo

CasNo.	552-41-0
Purity	≥98%
Formula	C₉H₁₀O₃
FormulaWt.	166.17
ChemicalName	1-(2-Hydroxy-4-methoxyphenyl)ethanone
IUPACName	1-(2-hydroxy-4-methoxyphenyl)ethanone
Synonym	4-O-Methylresacetophenone;Resacetophenone-4-methylether
MeltingPoint	49-52°C
Solubility	Solubleinwater.
Appearance	NeedleWhiteCrystallinePowderwithshine

ShippingandStorage

StoreTemp	Ambient
ShipTemp	Ambient

Downloads

InfoSheet	P0219InfoSheetPDF

References

YinJ,WuN,ZengF,etal.Paeonolinducesapoptosisinhumanovariancancercells.ActaHistochem.2013Oct;115(8):835-9.PMID:23768958.

WangYQ,DaiM,ZhongJC,etal.Paeonolinhibitsoxidizedlowdensitylipoprotein-inducedmonocyteadhesiontovascularendothelialcellsbyinhibitingthemitogenactivatedproteinkinasepathway.BiolPharmBull.2012;35(5):767-72.PMID:22687414.

LiYJ,BaoJX,XuJW,etal.Vasculardilationbypaeonol--amechanismstudy.VasculPharmacol.2010Sep-Oct;53(3-4):169-76.PMID:20643226.

KimSA,LeeHJ,AhnKS,etal.Paeonolexertsanti-angiogenicandanti-metastaticactivitiesthroughdownmodulationofAktactivationandinactivationofmatrixmetalloproteinases.BiolPharmBull.2009Jul;32(7):1142-7.PMID:19571375.

KongLD,ChengCH,TanRX.InhibitionofMAOAandBbysomeplant-derivedalkaloids,phenolsandanthraquinones.JEthnopharmacol.2004Apr;91(2-3):351-5.PMID:15120460.

ChouTC.Anti-inflammatoryandanalgesiceffectsofpaeonolincarrageenan-evokedthermalhyperalgesia.BrJPharmacol.2003Jul;139(6):1146-52.PMID:12871833.

品牌介绍

LKT Labs LKT Labs 是一家专注于防癌抗癌特殊化学品研究和开发的公司。主要提供：癌症药物、药物发现试剂盒、天然产物、广泛的生命科学研究试剂、定制合成。美国LKT Labs 是1988年在美国成立的，为全球提供先端的药物研发试剂、试剂盒、委托合成，并为药物生产企业提供原料，最近几年在农药、水产养殖业有很大程度的开发。在LKT Labs 可以找到在其他地方找不到的产品。试剂