Description
Paeonol was originally found in species of Paeonia, Arisaema, and Dioscorea. Paeonol exhibits anti-inflammatory, analgesic, neuromodulatory, vasodilatory, anticancer, anti-atherosclerotic, and anti-angiogenic activities. Paeonol inhibits carrageenan-induced thermal hyperalgesia and decreases production of TNF-α, IL-1β, COX-2, and iNOS. Paeonol also induces relaxation in aortic rings, potentially through inhibition of voltage-gated and receptor-gated Ca2+ channels. In ovarian cancer cells, paeonol decreases viability by increasing activation of caspase 3, downregulating expression of survivin, and inducing apoptosis. This compound also decreases expression of matrix metalloproteinases 2 and 9 (MMP2/9), suppresses activation of Akt, and prevents migration, tube formation, and vessel formation in vivo and in vitro. Additionally, paeonol decreases release of lactate dehydrogenase, expression of VCAM-1, and activation of JNK1/2, ERK1/2, and p38 MAPK, preventing monocyte adhesion to vascular endothelial cells. Paeonol also inhibits monoamine oxidases A and B (MAO-A, MAO-B).
References
Yin J, Wu N, Zeng F, et al. Paeonol induces apoptosis in human ovarian cancer cells. Acta Histochem. 2013 Oct;115(8):835-9. PMID: 23768958.
Wang YQ, Dai M, Zhong JC, et al. Paeonol inhibits oxidized low density lipoprotein-induced monocyte adhesion to vascular endothelial cells by inhibiting the mitogen activated protein kinase pathway. Biol Pharm Bull. 2012;35(5):767-72. PMID: 22687414.
Li YJ, Bao JX, Xu JW, et al. Vascular dilation by paeonol--a mechanism study. Vascul Pharmacol. 2010 Sep-Oct;53(3-4):169-76. PMID: 20643226.
Kim SA, Lee HJ, Ahn KS, et al. Paeonol exerts anti-angiogenic and anti-metastatic activities through downmodulation of Akt activation and inactivation of matrix metalloproteinases. Biol Pharm Bull. 2009 Jul;32(7):1142-7. PMID: 19571375.
Kong LD, Cheng CH, Tan RX. Inhibition of MAO A and B by some plant-derived alkaloids, phenols and anthraquinones. J Ethnopharmacol. 2004 Apr;91(2-3):351-5. PMID: 15120460.
Chou TC. Anti-inflammatory and analgesic effects of paeonol in carrageenan-evoked thermal hyperalgesia. Br J Pharmacol. 2003 Jul;139(6):1146-52. PMID: 12871833.
