LKT/PERINDOPRIL ERBUMINE/P1869/100 mg-免疫在线蚂蚁淘旗下平台

商品详细LKT/PERINDOPRIL ERBUMINE/P1869/100 mg

LKT/PERINDOPRIL ERBUMINE/P1869/100 mg

商品编号： P1869-100mg

品牌： lktlabs

市场价： ¥1640.00

美元价： 984.00

产地：美国(厂家直采)

公司：

产品分类：临床研究

公司分类： clinical_research

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

ProductIDP1869

CasNo.107133-36-8

Purity≥95%

Description
ProductInfo
ShippingandStorage
Downloads
References

Description

Perindoprilexhibitsantihypertensive,anti-fibrotic,neuroprotective,cognitionenhancing,anticancerchemotherapeutic,andchemopreventiveactivities.Perindoprilisanangiotensin-convertingenzyme(ACE)inhibitorthatdecreasesbloodpressure,vascularresistance,andvasoconstrictioninanimalmodelsandinclinicalsettings.Perindoprilalsoincreasesextracellularacetylcholine(ACh)andamelioratescognitiveimpairmentinanimalmodelsofvasculardementiaandAlzheimer’sdisease.Inotheranimalmodels,perindoprildecreasesactivityofNF-κBandlevelsofAT1R,TGF-β1,PDGF-BB,laminin,andhyaluronicacid,decreasinghepaticfibrosis.Perindoprildisplaysbothpro-angiogenicandanti-angiogenicactivitiesdependingontheanimalmodels.Indiabeticanimalmodelsofhindlimbischemia,perindoprilincreasesexpressionofeNOS,VEGF,bFGFandBO,increasingcapillarydensityandpost-ischemicrevascularization.Inanimalmodelsofhepatocellularcarcinoma,thiscompoundinhibitsVEGFexpressionandtubuleformation,preventingangiogenesisandtumordevelopment.

ProductInfo

ShippingandStorage

CasNo.	107133-36-8
Purity	≥95%
Formula	C₁₉H₃₂N₂O₅•C₄H₁₁N
FormulaWt.	441.60
IUPACName	(2S,3aS,7aS)-1-[(2S)-2-[[(2S)-1-ethoxy-1-oxopentan-2-yl]amino]propanoyl]-2,3,3a,4,5,6,7,7a-octahydroindole-2-carboxylicacid;2-methylpropan-2-amine
MeltingPoint	100-101°C
Appearance	WhiteCrystalPowder

StoreTemp	Ambient
ShipTemp	Ambient

Downloads

InfoSheet	P1869InfoSheetPDF

References

YamadaK,HoritaT,TakayamaM,etal.Effectofacentrallyactiveangiotensinconvertingenzymeinhibitor,perindopril,oncognitiveperformanceinchroniccerebralhypo-perfusionrats.BrainRes.2011Nov3;1421:110-20.PMID:21981801.

GaoL,YuDM.Molecularmechanismoflimbs"postischemicrevascularizationimprovedbyperindoprilindiabeticrats.ChinMedJ(Engl).2008Nov5;121(21):2129-33.PMID:19080171.

LiX,MengY,YangXS,etal.ACEIattenuatestheprogressionofCCl4-inducedrathepaticfibrogenesisbyinhibitingTGF-beta1,PDGF-BB,NF-kappaBandMMP-2,9.WorldJGastroenterol.2005Aug21;11(31):4807-11.PMID:16097048.

YoshijiH,KuriyamaS,KawataM,etal.Theangiotensin-I-convertingenzymeinhibitorperindoprilsuppressestumorgrowthandangiogenesis:possIBLeroleofthevascularendothelialgrowthfactor.ClinCancerRes.2001Apr;7(4):1073-8.PMID:11309359.

RicherC,DoussauMP,GiudicelliJF.Perindopril,anewconvertingenzymeinhibitor:systemicandregionalhemodynamicsandsympathoinhibitoryeffectsinspontaneouslyhypertensiverats.JCardiovascPharmacol.1986Mar-Apr;8(2):346-57.PMID:2422474.

品牌介绍

LKT Labs LKT Labs 是一家专注于防癌抗癌特殊化学品研究和开发的公司。主要提供：癌症药物、药物发现试剂盒、天然产物、广泛的生命科学研究试剂、定制合成。美国LKT Labs 是1988年在美国成立的，为全球提供先端的药物研发试剂、试剂盒、委托合成，并为药物生产企业提供原料，最近几年在农药、水产养殖业有很大程度的开发。在LKT Labs 可以找到在其他地方找不到的产品。试剂