Phentolamine is a nonselective α-adrenergic receptor antagonist that exhibits vasodilatory and antihypertensive activities. Phentolamine is occasionally used to treat erectile dysfunction. In vivo, phentolamine inhibits fructose-induced increases in blood pressure and activates ATP-sensitive K+ channels, altering Ca2+ signaling.
| Cas No. | 65-28-1 |
|---|---|
| Purity | ≥98% |
| Formula | C17H19N3O • CH3SO3H |
| Formula Wt. | 377.46 |
| Chemical Name | 3-[[(4,5-Dihydro-1H-imidazol-2-yl)methyl](4-methyl- phenyl)amino]phenol methanesulfonate |
| IUPAC Name | 3-[N-(4,5-dihydro-1H-imidazol-2-ylmethyl)-4-methylanilino]phenol;methanesulfonicacid |
| Synonym | Phentolamine mesylate; Regitine; Rogitine |
| Melting Point | 177-181°C |
| Solubility | Soluble in water, alcohol and chloroform. |
| Appearance | White Crystal Powder |
| Store Temp | Ambient |
|---|---|
| Ship Temp | Ambient |
| Info Sheet | P2818 Info Sheet PDF |
|---|
Zhou K, Kumar U, Yuen VG, et al. The effects of phentolamine on fructose-fed rats. Can J Physiol Pharmacol. 2012 Aug;90(8):1075-85. PMID: 22783820.
Ahn SW, Kim SH, Kim JH, et al. Phentolamine inhibits the pacemaker activity of mouse interstitial cells of Cajal by activating ATP-sensitive K+ channels. Arch Pharm Res. 2010 Mar;33(3):479-89. PMID: 20361315.
Dinsmore WW, Wyllie MG. Vasoactive intestinal polypeptide/phentolamine for intracavernosal injection in erectile dysfunction. BJU Int. 2008 Sep;102(8):933-7. PMID: 18485029.
