Phentolamineisanonselectiveα-adrenergicreceptorantagoNISTthatexhibitsvasodilatoryandantihypertensiveactivities.Phentolamineisoccasionallyusedtotreaterectiledysfunction.Invivo,phentolamineinhibitsfructose-inducedincreasesinbloodpressureandactivatesATP-sensitiveK+channels,alteringCa2+signaling.
| CasNo. | 65-28-1 |
|---|---|
| Purity | ≥98% |
| Formula | C17H19N3O•CH3SO3H |
| FormulaWt. | 377.46 |
| ChemicalName | 3-[[(4,5-Dihydro-1H-imidazol-2-yl)methyl](4-methyl-phenyl)amino]phenolmethanesulfonate |
| IUPACName | 3-[N-(4,5-dihydro-1H-imidazol-2-ylmethyl)-4-methylanilino]phenol;methanesulfonicacid |
| Synonym | Phentolaminemesylate;Regitine;Rogitine |
| MeltingPoint | 177-181°C |
| Solubility | Solubleinwater,alcoholandchloroform. |
| Appearance | WhiteCrystalPowder |
| StoreTemp | Ambient |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | P2818InfoSheetPDF |
|---|
ZhouK,KumarU,YuenVG,etal.Theeffectsofphentolamineonfructose-fedrats.CanJPhysiolPharmacol.2012Aug;90(8):1075-85.PMID:22783820.
AhnSW,KimSH,KimJH,etal.PhentolamineinhibitsthepacemakeractivityofmouseinterstitialcellsofCajalbyactivatingATP-sensitiveK+channels.ArchPharmRes.2010Mar;33(3):479-89.PMID:20361315.
DinsmoreWW,WyllieMG.Vasoactiveintestinalpolypeptide/phentolamineforintracavernosalinjectioninerectiledysfunction.BJUInt.2008Sep;102(8):933-7.PMID:18485029.
