LKT/PIPERLONGUMINE/P3561/25 mg-免疫在线蚂蚁淘旗下平台

商品详细LKT/PIPERLONGUMINE/P3561/25 mg

LKT/PIPERLONGUMINE/P3561/25 mg

商品编号： P3561-25mg

品牌： lktlabs

市场价： ¥1140.00

美元价： 684.00

产地：美国(厂家直采)

公司：

产品分类：临床研究

公司分类： clinical_research

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

ProductIDP3561

CasNo.20069-09-4

Purity≥98%

Description
ProductInfo
ShippingandStorage
Downloads
References

Description

PiperlongumineisfoundinseveralspeciesofthePiperplantanddisplaysmanybeneficialcharacteristics,includingantithrombotic,anti-inflammatory,anti-atherosclerotic,andchemotherapeuticactivities.PiperlonguminedirectlyinhibitsthromboxaneA2(TxA2)receptors,inhibitingplateletaggregationinvivo.PiperlonguminealsodecreasesNF-κBactivationandinhibitsPDGFRsignalinginvivo,inhibitingcellmigrationanddecreasingatheroscleroticplaqueformation.Inacellularmodelofprostatecancer,piperlongumineinhibitsNF-κBactivityanddecreasesexpressionofIL-6,IL-8,MMP9,andICAM-1,decreasingcellinvasionandgrowth;inaseparatestudyusingasimilarmodel,thiscompoundpreventstranscriptionofandrogenreceptors,decreasingandrogenreceptorproteinlevels.Inseveralothercellularmodelsofcancer(includingglioblastomamultiformeandcoloncancer),piperlongumineinhibitstheubiquitin-proteasomesystem,likelyatapre-proteasomalstage,increasingreactiveoxygenspecies(ROS)andstimulatingactivationofp38,resultinginautophagyandcelldeath.ItisanovelCRM1inhibitor.

ProductInfo

CasNo.	20069-09-4
Purity	≥98%
Formula	C₁₇H₁₉NO₅
FormulaWt.	317.34
ChemicalName	(E)-1-(3-(3,4,5-Trimethoxyphenyl)acryloyl)-5,6-dihydropyridin-2(1H)-one
IUPACName	1-[(E)-3-(3,4,5-trimethoxyphenyl)prop-2-enoyl]-2,3-dihydropyridin-6-one
Synonym	1-[(2E)-3,4,5-trimethoxyphenyl)prop-2-enoyl]-5,6-dihydropyridin-2-(1H)-one;Piplartine
Solubility	DMSO(~25mg/ml)
Appearance	YellowPowder

ShippingandStorage

StoreTemp	-20°C
ShipTemp	Ambient

Downloads

MSDS	P3561MSDSPDF
InfoSheet	P3561InfoSheetPDF

References

GinzburgS,GolovineKV,MakhovPB,etal.PiperlongumineinhibitsNF-κBactivityandattenuatesaggressivegrowthcharacteristicsofprostatecancercells.Prostate.2013Oct22.[Epubaheadofprint].PMID:24151226.

WangY,WangJW,XiaoX,etal.Piperlongumineinducesautophagybytargetingp38signaling.CellDeathDis.2013Oct3;4:e824.PMID:24091667.

LiuJM,PanF,LiL,etal.PiperlongumineselectivelykillsglioblastomamultiformecellsviareactiveoxygenspeciesaccumulationdependentJNKandp38activation.BiochemBiophysResCommun.2013Jul19;437(1):87-93.PMID:23796709.

JarviusM,FryknäsM,D"ArcyP,etal.Piperlongumineinducesinhibitionoftheubiquitin-proteasomesystemincancercells.BiochemBiophysResCommun.2013Feb8;431(2):117-23.PMID:23318177.

SonDJ,KimSY,HanSS,etal.PiperlongumineinhibitsatheroscleroticplaqueformationandvascularsmoothmusclecellproliferationbysuppressingPDGFreceptorsignaling.BiochemBiophysResCommun.2012Oct19;427(2):349-54.PMID:22995306.

GolovineKV,MakhovPB,TeperE,etal.Piperlongumineinducesrapiddepletionoftheandrogenreceptorinhumanprostatecancercells.Prostate.2013Jan;73(1):23-30.PMID:22592999.

IwashitaM,OkaN,OhkuboS,etal.Piperlongumine,aconstituentofPiperlongumL.,inhibitsrabbitplateletaggregationasathromboxaneA(2)receptorantagoNIST.EurJPharmacol.2007Sep10;570(1-3):38-42.PMID:17618620.

NiuM,XuX,ShenY,YaoYetal.,Piperlongumineisanovelnuclearexportinhibitorwithpotentanticanceractivity.ChemBiolInteract.2015Jul25;237:66-72.PMID:26026911DOI:10.1016/j.cbi.2015.05.016.

品牌介绍

LKT Labs LKT Labs 是一家专注于防癌抗癌特殊化学品研究和开发的公司。主要提供：癌症药物、药物发现试剂盒、天然产物、广泛的生命科学研究试剂、定制合成。美国LKT Labs 是1988年在美国成立的，为全球提供先端的药物研发试剂、试剂盒、委托合成，并为药物生产企业提供原料，最近几年在农药、水产养殖业有很大程度的开发。在LKT Labs 可以找到在其他地方找不到的产品。试剂