LKT/PLASMINOGEN ACTIVATOR INHIBITOR 1/P4403/0.5 mg-免疫在线蚂蚁淘旗下平台

商品详细LKT/PLASMINOGEN ACTIVATOR INHIBITOR 1/P4403/0.5 mg

LKT/PLASMINOGEN ACTIVATOR INHIBITOR 1/P4403/0.5 mg

商品编号： P4403-0.5mg

品牌： lktlabs

市场价： ¥1260.00

美元价： 756.00

产地：美国(厂家直采)

公司：

产品分类：临床研究

公司分类： clinical_research

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

ProductIDP4403

CasNo.

Purity≥95%

Description
ProductInfo
ShippingandStorage
Downloads
References

Description

Plasminogenactivatorinhibitor1(PAI-1)isapeptideproteaseinhibitorthatexhibitsproliferation-enhancingactivityincancermodels.PAI-1isproducedbythrombinactivationofprotease-activatedreceptor1(PAR1)andisclinicallyusedasabioMarkerforheartdisease.PAI-1increasescellproliferationandtumorsizeofHeLaxenograftsinsomemodelsandmaybeover-expressedincanceroustissue.Inotheranimalmodelsofcancer,PAI-1exhibitsanti-apoptoticactivitythroughamechanismthatinvolvedactivationofplasminandinhibitionofFas/FasLsignaling.PAI-1alsodisplayspro-fibroticcharacteristicsandplaysaroleintype1diabeticosteoporosis;itpromotesproliferationofpulmonaryfibroblasts,enhancestheirtransitiontomyofibroblasts,andincreasescollagensynthesisandactivationofERKandAkt.

ProductInfo

ShippingandStorage

Purity	≥95%
Formula	C₂₇H₄₇N₉O₉S
FormulaWt.	673.79
Synonym	PAI-1
Appearance	Whitetooffwhitepowder

StoreTemp	-20°C
ShipTemp	Ambient

Downloads

InfoSheet	P4403InfoSheetPDF

References

GomesGiacoiaE,MiyakeM,LawtonA,etal.PAI-1LeadstoG1-phaseCellCycleProgressionthroughCyclinD3/CDK4/6Up-regulation.MolCancerRes.2014Jan24.[Epubaheadofprint].PMID:24464915.

TamuraY,KawaoN,OkadaK,etal.Plasminogenactivatorinhibitor-1isinvolvedinstreptozotocin-inducedbonelossinfemalemice.Diabetes.2013Sep;62(9):3170-9.PMID:23715621.

ZhangYP,WangWL,LiuJ,etal.Plasminogenactivatorinhibitor-1promotestheproliferationandinhibitstheapoptosisofpulmonaryfibroblastsbyCa(2+)signaling.ThrombRes.2013Jan;131(1):64-71.PMID:23021499.

FangH,PlacencioVR,DeClerckYA.ProtumOrigenicactivityofplasminogenactivatorinhibitor-1throughanantiapoptoticfunction.JNatlCancerInst.2012Oct3;104(19):1470-84.PMID:22984202.

McEachronTA,ChurchFC,MackmanN.Regulationofthrombin-inducedplasminogenactivatorinhibitor-1in4T1murinebreastcancercells.BloodCoagulFibrinolysis.2011Oct;22(7):576-82.PMID:21799402.

品牌介绍

LKT Labs LKT Labs 是一家专注于防癌抗癌特殊化学品研究和开发的公司。主要提供：癌症药物、药物发现试剂盒、天然产物、广泛的生命科学研究试剂、定制合成。美国LKT Labs 是1988年在美国成立的，为全球提供先端的药物研发试剂、试剂盒、委托合成，并为药物生产企业提供原料，最近几年在农药、水产养殖业有很大程度的开发。在LKT Labs 可以找到在其他地方找不到的产品。试剂