Description
PP-1 inhibits members of the Src kinase family and displays antioxidative, anti-inflammatory, and anti-arrhythmic characteristics. In an in vitro model of oxidative stress, PP-1 inhibits hydrogen peroxide-induced production of macrophage migration inhibitory factor (MIF). PP-1 decreases total and phosphorylated levels of Src and increases connexin-43 levels and gap junction communication. Additionally, PP-1 decreases ventricular tachycardia and sudden death in animal models of arrhythmia.
References
Rao F, Deng CY, Zhang QH, et al. Involvement of Src tyrosine kinase and protein kinase C in the expression of macrophage migration inhibitory factor induced by H2O2 in HL-1 mouse cardiac muscle cells. Braz J Med Biol Res. 2013 Sep;46(9):746-51. PMID: 24036910.
Sovari AA, Iravanian S, Dolmatova E, et al. Inhibition of c-Src tyrosine kinase prevents angiotensin II-mediated connexin-43 remodeling and sudden cardiac death. J Am Coll Cardiol. 2011 Nov 22;58(22):2332-9. PMID: 22093512.
Wijetunge S, Hughes AD. Src family tyrosine kinases mediate contraction of rat isolated tail arteries in response to a hyposmotic stimulus. J Hypertens. 2007 Sep;25(9):1871-8. PMID: 17762651.
