PropafenoneisaclassIcanti-arrhythmiccompoundthatinhibitsβ-adrenergicreceptors,slowsNa+andCa2+influx,anddecreasesoverallcellularexcitABIlity.PropafenoneinhibitsKv1.4K+channelsandhumancardiactwopore-domain(K2P2)K+channels.Additionally,propafenoneinhibitsexpressionoftyrosinase,TRP-1,andTRP-2anddecreasesproductionofcAMP,suppressingmelanogenesisinvitro.
| CasNo. | 34183-22-7 |
|---|---|
| Purity | ≥98% |
| Formula | C21H27NO3•HCl |
| FormulaWt. | 377.91 |
| ChemicalName | 1-[2-[2-Hydroxy-3-(propylamino)propoxy]phenyl]-3-phenyl-1propanonehydrochloride |
| IUPACName | 1-[2-[2-hydroxy-3-(propylamino)propoxy]phenyl]-3-phenylpropan-1-one;hydrochloride |
| Synonym | Arythmol;Pronon;Rythmol;Rytmonorm |
| MeltingPoint | 171-174°C |
| Solubility | Solubleinbasicloweraliphaticalcohols,chloroformandhotwater.Slightlysolubleincoldwater.Insolubleinether. |
| Appearance | WhiteCrystalPowder |
| StoreTemp | Ambient |
|---|---|
| ShipTemp | Ambient |
| MSDS | P6852MSDSPDF |
|---|---|
| InfoSheet | P6852InfoSheetPDF |
SchmidtC,WiedmannF,SchweizerPA,etal.ClassIantiarrhythmicdrugsinhibithumancardiactwo-pore-domainK(+)(K2P2)channels.EurJPharmacol.2013Dec5;721(1-3):237-48.PMID:24070813.
HuhS,JungE,LeeJ,etal.Mechanismsofmelanogenesisinhibitionbypropafenone.ArchDermatolRes.2010Sep;302(7):561-5.PMID:20549222.
TianL,JiangX,RasmussonR,etal.EffectofpropafenoneonKv1.4inactivation.JPhysiolBiochem.2006Dec;62(4):263-70.PMID:17615952.
