Propafenone is a class Ic anti-arrhythmic compound that inhibits β-adrenergic receptors, slows Na+ and Ca2+ influx, and decreases overall cellular excitability. Propafenone inhibits Kv1.4 K+ channels and human cardiac two pore-domain (K2P2) K+ channels. Additionally, propafenone inhibits expression of tyrosinase, TRP-1, and TRP-2 and decreases production of cAMP, suppressing melanogenesis in vitro.
| Cas No. | 34183-22-7 |
|---|---|
| Purity | ≥98% |
| Formula | C21H27NO3 • HCl |
| Formula Wt. | 377.91 |
| Chemical Name | 1-[2-[2-Hydroxy-3-(propylamino)propoxy]phenyl]-3-phenyl-1propanone hydrochloride |
| IUPAC Name | 1-[2-[2-hydroxy-3-(propylamino)propoxy]phenyl]-3-phenylpropan-1-one;hydrochloride |
| Synonym | Arythmol; Pronon; Rythmol; Rytmonorm |
| Melting Point | 171-174°C |
| Solubility | Soluble in basic lower aliphatic alcohols, chloroform and hot water. Slightly soluble in cold water. Insoluble in ether. |
| Appearance | White Crystal Powder |
| Store Temp | Ambient |
|---|---|
| Ship Temp | Ambient |
| MSDS | P6852 MSDS PDF |
|---|---|
| Info Sheet | P6852 Info Sheet PDF |
Schmidt C, Wiedmann F, Schweizer PA, et al. Class I antiarrhythmic drugs inhibit human cardiac two-pore-domain K(+) (K2P2) channels. Eur J Pharmacol. 2013 Dec 5;721(1-3):237-48. PMID: 24070813.
Huh S, Jung E, Lee J, et al. Mechanisms of melanogenesis inhibition by propafenone. Arch Dermatol Res. 2010 Sep;302(7):561-5. PMID: 20549222.
Tian L, Jiang X, Rasmusson R, et al. Effect of propafenone on Kv1.4 inactivation. J Physiol Biochem. 2006 Dec;62(4):263-70. PMID: 17615952.
