ProstaglandinE1(PGE1)isanendogenousprostaglandinsynthesizedfromlinolenicacid.PGE1isclinicallyusedforitsvasodilatoryactivityasatreatmentforerectiledysfunction.PGE1alsoexhibitsnephroprotectiveandpro-angiogenicactivities.PGE1decreasessmallintestinemucosalesionsinanimalmodelsofintestinalischemia/reperfusion.PGE1alsoimprovesrenalfunctioninsubjectwithrenaldysfunctionorrenalfailure.Additionally,PGE1enhancesVEGFproductioninanimalmodelsofischemia.
| CasNo. | 745-65-3 |
|---|---|
| Purity | ≥98% |
| Formula | C20H34O5 |
| FormulaWt. | 354.48 |
| ChemicalName | (11a,13E,15S)-11,15-Dihydroxy-9-oxoprost-13-enoicacid |
| IUPACName | 7-[(1R,2R,3R)-3-hydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]-5-oxocyclopentyl]heptanoicacid |
| Synonym | AlprostADIl;PGE1;Caverject;Muse;Prostandin;ProstinVR |
| MeltingPoint | 115-116°C |
| Solubility | Solubleinethanol(5mg/mL)oracetone(10mg/mL). |
| Appearance | WhiteNeedleCrystal |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| MSDS | P6956MSDSPDF |
|---|---|
| InfoSheet | P6956InfoSheetPDF |
HanchanaleV,EardleyI.Alprostadilforthetreatmentofimpotence.ExpertOpinPharmacother.2014Feb;15(3):421-8.PMID:24369066.
BrasileiroJL,InoyeCM,AydosRD,etal.IschemiaandreperfusionofratsmallintestineusingpentoxyfillineandprostaglandinE1.ActaCirBras.2013Nov;28(11):767-73.PMID:24316743.
LiuWJ,ZhangBC,GuoR,etal.Renoprotectiveeffectofalprostadilincombinationwithstatinsinpatientswithmildtomoderaterenalfailureundergoingcoronaryangiography.ChinMedJ(Engl).2013;126(18):3475-80.PMID:24034093.
InoueH,AiharaM,TomiokaM,etal.Specificenhancementofvascularendothelialgrowthfactor(VEGF)productioninischemicregionbyalprostadil--potentialtherapeuticapplicationinpharmaceuticalregenerativemedicine.JPharmacolSci.2013;122(2):158-61.PMID:23728380.
