Description
Protocatechuicacidisapolyphenolfoundinmanyplantsandfoods;itsexhibitsanticancerchemotherapeutic,chemopreventive,antiviral,anti-anginal,cardioprotective,antioxidative,andneuroprotectiveactivities.ProtocatechuicaciddecreasescellmigrationandinvasionofmelanomacellsthroughtargetingofPKC/RhoBactivationandresultingdecreasesinNF-κBactivationandMatrixmetalloproteinase2(MMP2)expression.Protocatechuicacidalsoinducesapoptosisingastricadenocarcinomacells,increasingactivationofJNKandp38MAPK.AdditionallythiscompoundinhibitstopoisomeraseII.Inavianmodelsofinfectiousbursaldiseasevirus,protocatechuicacidincreaseslymphocyteproliferationandvirusclearance.Protocatechuicacidalsodisplaysbenefitinischemicconditions,decreasingfattyacidoxidationintherodentheart.Thiscompoundpreventsoxidativestress-inducedapoptosisinPC12neuronsaswell,inhibitingchangesinmitochondrialmembranepotential,caspase3activation,anddecreasesinBcl-2andglutathione.
References
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