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商品详细LKT/PROTODIOSCIN/P7057/25 mg
LKT/PROTODIOSCIN/P7057/25 mg
LKT/PROTODIOSCIN/P7057/25 mg
商品编号: P7057-25mg
品牌: lktlabs
市场价: ¥10320.00
美元价: 6192.00
产地: 美国(厂家直采)
公司:
产品分类: 临床研究
公司分类: clinical_research
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References

Description

Protodioscin is a saponin originally found in the rhizomes of several species of Dioscorea. Protodioscin exhibits cardioprotective, anti-hyperlipidemic, and anticancer activities. Protodioscin increases activities of the Na+/K+ ATPase and Ca2+/Mg2+ ATPase, protecting cardiomyocytes under anoxic conditions mimicking ischemic injury. In animal models, protodioscin decreases levels of triglycerides, LDL, and total cholesterol and increases levels of HDL in serum. In various cancer cell lines, metabolites of this compound exhibit anti-proliferative activity. Additionally, protodioscin downregulates levels of Bcl-2 and cyclin B1 and upregulates levels of Bax, inducing G2/M phase cell cycle arrest and apoptosis.

Product Info

Cas No.

55056-80-9

Purity

≥98%

Formula

C50H82O22

Formula Wt.

1049.19

Appearance

White Crystal Powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

Info Sheet

P7057 Info Sheet PDF

References

Wang T, Choi RC, Li J, et al. Antihyperlipidemic effect of protodioscin, an active ingredient isolated from the rhizomes of Dioscorea nipponica. Planta Med. 2010 Oct;76(15):1642-6. PMID: 20509104.

Ning Z, Li YK, Zhou Y. Effect and mechanism of methyl protodioscin in protecting cardiomyocytes against anoxia/reoxygenation injury. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2010 Apr;30(4):407-9. PMID: 20669680.

He X, Qiao A, Wang X, et al. Structural identification of methyl protodioscin metabolites in rats' urine and their antiproliferative activities against human tumor cell lines. Steroids. 2006 Sep;71(9):828-33. PMID: 16797625.

Wang G, Chen H, Huang M, et al. Methyl protodioscin induces G2/M cell cycle arrest and apoptosis in HepG2 liver cancer cells. Cancer Lett. 2006 Sep 8;241(1):102-9. PMID: 16458429.

Hu K, Yao X. The cytotoxicity of methyl protodioscin against human cancer cell lines in vitro. Cancer Invest. 2003 Jun;21(3):389-93. PMID: 12901285.

Hu K, Yao X. Protodioscin (NSC-698 796): its spectrum of cytotoxicity against sixty human cancer cell lines in an anticancer drug screen panel. Planta Med. 2002 Apr;68(4):297-301. PMID: 11988850.

品牌介绍
LKT Labs LKT Labs 是一家专注于防癌抗癌特殊化学品研究和开发的公司。主要提供:癌症药物、药物发现试剂盒、天然产物、广泛的生命科学研究试剂、定制合成。美国LKT Labs 是1988年在美国成立的,为全球提供先端的药物研发试剂、试剂盒、委托合成,并为药物生产企业提供原料,最近几年在农药、水产养殖业有很大程度的开发。在LKT Labs 可以找到在其他地方找不到的产品。 试剂