Description
Pyridoxine is a derivative of vitamin B6. In a clinical setting, pyridoxine decreases photosensitivity in subjects with erythropoietic protoporphyria. Pyridoxine exhibits antioxidative activity, inhibiting oxidized LDL-induced generation of superoxide anions, decreases in PKC activity, and decreases in p-eNOS and NO levels. In platelets, pyridoxine increases NO levels and inhibits platelet aggregation, displaying some antithrombotic benefit as well. Pyridoxine increases expression of IGF-binding protein 3 (IGF-BP3) in breast cancer cells through a p53-mediated mechanism. In synaptosomes, this compound inhibits release of glutamate but suppressing cellular influx of Ca2+ and activity of PKC. In erythrocytes exposed to high concentrations of glucose, pyridoxine decreases lipid peroxidation and protein glycosylation and increases Na2+/K+ ATPase activity.
References
Xie L, Liu Z, Lu H, et al. Pyridoxine inhibits endothelial NOS uncoupling induced by oxidized low-density lipoprotein via the PKCα signaling pathway in human umbilical vein endothelial cells. Br J Pharmacol. 2012 Feb;165(3):754-64. PMID: 21797845.
Nakari M, Kanouchi H, Oka T. High dose of pyridoxine induces IGFBP-3 mRNA expression in MCF-7 cells and its induction is inhibited by the p53-specific inhibitor pifithrin-α. J Nutr Sci Vitaminol (Tokyo). 2011;57(4):280-4. PMID: 22041910.
Yang TT, Wang SJ. Pyridoxine inhibits depolarization-evoked glutamate release in nerve terminals from rat cerebral cortex: a possible neuroprotective mechanism? J Pharmacol Exp Ther. 2009 Oct;331(1):244-54. PMID: 19628631.
Wu Y, Liu Y, Han Y, et al. Pyridoxine increases nitric oxide biosynthesis in human platelets. Int J Vitam Nutr Res. 2009 Mar;79(2):95-103. PMID: 20108211.
Jain SK, Lim G. Pyridoxine and pyridoxamine inhibits superoxide radicals and prevents lipid peroxidation, protein glycosylation, and (Na+ + K+)-ATPase activity reduction in high glucose-treated human erythrocytes. Free Radic Biol Med. 2001 Feb 1;30(3):232-7. PMID: 11165869.
Ross JB, Moss MA. Relief of the photosensitivity of erythropoietic protoporphyria by pyridoxine. J Am Acad Dermatol. 1990 Feb;22(2 Pt 2):340-2. PMID: 2303590.
