Description
Warfarinisanorallyavailableantithromboticcommonlyusedforpreventingbloodclotformationandmigration.Warfarinisaderivativeofcoumarin;theRenantiomerissomewhatlesspotentthantheSenantiomer.Thiscoumarininhibitsthesubunit1ofthevitaminKepoxidereductasecomplex(VKORC1),depletingthereducedformofvitaminK(KH2)andinhibitingtheformationofcoagulationfactorsII,VII,IX,andX.Warfarinhasarelativelyslowonsetandrequires1to2daystotakeeffect.ThiscompoundishighlysensitivetoawidevarietyofgeneticpolymorphismsandismetabolizedbycytochromeP4502C9;italsointeractswithmanyothermedicationsandfoods,requiringdiligentactivitymonitoring.
References
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