Description
R,S-Sulforaphaneisasyntheticisothiocyanate.R-Sulforaphaneisthenaturally-occurringisomer,foundinbroccoli.Thiscompoundexhibitsantioxidative,neuroprotective,anti-inflammatory,anti-atherosclerotic,neuromodulatory,cardioprotective,anticoagulant,antibiotic,anticancerchemotherapeutic,andchemopreventiveactivities;researchsuggeststhattheR-isomermaybemorebioactivethantheS-isomer.R,S-SulforaphaneinducesactivityandexpressionofphaseIIenzymes,inhibitsthearylhydrocarbonreceptor,anddownregulatesexpressionofHDACsandSTAT5.Incellularandanimalmodelsofmelanoma,thiscompoundinhibitstumorgrowthandcellproliferation.R,S-Sulforaphanealsoinducesautophagy.InanimalmodelsofAlzheimer’sdisease,R,S-sulforaphanelessenscognitiveimpairment.Additionally,thiscompoundincreasesactivityofNrf2andexpressionofcatalase,protectingagainstUV-inducedoxidativedamageinexvivomodels.Inotheranimalmodels,R,S-sulforaphaneinhibitsTNF-α-inducedadhesionofmonocytestoepithelialcellsanddecreaseslevelsofVCAM-1.Inmyocytes,thiscompoundpreventsangiotensinII-inducedhypertrophy.Additionally,R,S-sulforaphaneinhibitsplateletaggregationbysuppressingPI3K/Aktsignaling.R,S-SulforaphanealsodisplaysantibacterialefficacyagainstEscherichia.Pleasenote:Thiscompoundisaneatliquidatroomtemperature,cleartoslightlyyellowincolor.Itisnotdissolvedinsolvent.InsmallquantitiesthematerialwillcoatthesidesoftheampuleitisshippedinandmayappeartobeinvisIBLe,oritmaybetrappedinthetipoftheampule.Washtheupperandlowerpartsoftheampoulewithsolventtoensureallofthematerialisobtained.
