AS-604850isaninhibitorofp110γPI3Kthatexhibitsanti-inflammatoryandimmunosuppressiveactivities.Inanimalmodelsofexperimentalautoimmuneencephalitis(EAE),AS-604850decreasesthenumberofleukocytesinfiltratedintotheCNSandamelioratesdiseasesymptoms.AS-604850alsodecreaseschemotacticresponsesofeosinophilstoplateletactivatingfactor(PAF).
| CasNo. | 48449-76-7 |
|---|---|
| Purity | ≥98% |
| Formula | C11H5F2NO4S |
| FormulaWt. | 285.22 |
| Appearance | WhiteCrystalPowder |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | A7202InfoSheetPDF |
|---|
LiH,ParkD,ABDul-MuneerPM,etal.PI3Kγinhibitionalleviatessymptomsandincreasesaxonnumberinexperimentalautoimmuneencephalomyelitismice.Neuroscience.2013Dec3;253:89-99.PMID:24012746.
HasanAM,Mourtada-MaarabouniM,HameedMS,etal.Phosphoinositide3-kinasegammamediateschemotacticresponsesofhumaneosinophilstoplatelet-activatingfactor.IntImmunopharmacol.2010Sep;10(9):1017-21.PMID:20685403.
