AscomycinisanethylanalogofFK506thatwasinitiallyproducedbyspeciesofStreptomyces.AscomycinbindsFK506bindingprotein12andtheresultingcomplexinhibitscalcineurin/proteinphosphatase2B(PP2B),alteringpeptidyl-prolylisomeraseactivityoftheenzyme.Ascomycinexhibitsimmunosuppressive,anti-inflammatory,andanticonvulsantactivities.Clinically,ascomycinisusedtotreatorgantransplantrejectionandinflammatoryskindiseases.
| CasNo. | 104987-12-4 |
|---|---|
| Purity | ≥98% |
| Formula | C43H69NO12 |
| FormulaWt. | 792.01 |
| MeltingPoint | 162-163°C |
| Solubility | SolubleinDMSO |
| Appearance | WhitePowder |
| StoreTemp | 4°C |
|---|---|
| ShipTemp | Ambient |
| MSDS | A7208MSDSPDF |
|---|---|
| InfoSheet | A7208InfoSheetPDF |
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PahlA,KellerU.FK-506-bindingproteinsfromstreptomycetesproducingimmunosuppressivemacrolactonesoftheFK-506type.JBacteriol.1992Sep;174(18):5888-94.PMID:1381710.
