Description
Astilbinisaflavonoidfoundinseveralplants,includingspeciesofEngelhardiaandSmilax.Astilbindisplaysanticancer,antioxidative,anti-inflammatory,andimmunosuppressiveactivities.Invitro,astilbininhibitsexpressionofIL-1β,IL-6,IL-10,MCP-1,andTNF-α,aswellasactivityofhorserADIshperoxidaseandmyeloperoxidase.ThiscompoundalsoinhibitsmaturationofandantigenpresentationbydendriticcellsandactivationandproliferationofTcells.AstilbindownregulatesNF-κBandc-Mycandinducescellcyclearrestandcaspase-mediatedapoptosisinhepatomacells.Additionally,astilbinalsoinhibitsreleaseofprostaglandinE2.
References
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