Description
Astilbin is a flavonoid found in several plants, including species of Engelhardia and Smilax. Astilbin displays anticancer, antioxidative, anti-inflammatory, and immunosuppressive activities. In vitro, astilbin inhibits expression of IL-1β, IL-6, IL-10, MCP-1, and TNF-α, as well as activity of horseradish peroxidase and myeloperoxidase. This compound also inhibits maturation of and antigen presentation by dendritic cells and activation and proliferation of T cells. Astilbin downregulates NF-κB and c-Myc and induces cell cycle arrest and caspase-mediated apoptosis in hepatoma cells. Additionally, astilbin also inhibits release of prostaglandin E2.
References
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Huang H, Cheng Z, Shi H, et al. Isolation and characterization of two flavonoids, engeletin and astilbin, from the leaves of Engelhardia roxburghiana and their potential anti-inflammatory properties. J Agric Food Chem. 2011 May 11;59(9):4562-9. PMID: 21476602.
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Lucas-Filho MD, Silva GC, Cortes SF, et al. ACE inhibition by astilbin isolated from Erythroxylum gonocladum (Mart.) O.E. Schulz. Phytomedicine. 2010 Apr;17(5):383-7. PMID: 19879122.
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