4000-520-616
欢迎来到免疫在线!(蚂蚁淘生物旗下平台)  请登录 |  免费注册 |  询价篮
主营:主营:防癌抗癌特殊化学品试剂
咨询热线电话
4000-520-616
当前位置: 首页 > 产品中心 > clinical_research > LKT/壬二酸/A9817/5克
商品详细LKT/壬二酸/A9817/5克
LKT/壬二酸/A9817/5克
LKT/壬二酸/A9817/5克
商品编号: A9817-5g
品牌: lktlabs
市场价: ¥600.00
美元价: 360.00
产地: 美国(厂家直采)
公司:
产品分类: 临床研究
公司分类: clinical_research
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References

Description

Azelaic acid is a dicarboxylic acid originally found in Arabidopsis that exhibits anti-inflammatory activity. Azelaic acid is clinically used to treat rosacea, acne, and hyperpigmentary disorders. Azelaic acid directly inhibits kallikrein 5 (KLK5), downregulating expression of KLK5, toll-like receptor 2 (TLR 2), and cathelicidin, and suppresses activity of serine proteases in vitro, in vivo, and in clinical settings. In PUFA-treated fibroblasts, azelaic acid decreases generation of ROS and upregulates expression of antioxidative enzymes, inhibiting cell damage; agonist activity at PPARγ is thought to drive these effects. Azelaic acid also inhibits proliferation of melanocytes. This compound displays anticancer potential as well, inhibiting the proliferation of cutaneous melanoma cells due to suppression of mitochondrial oxidoreductive activity and DNA synthesis.

Product Info

Cas No.

123-99-9

Purity

≥98%

Formula

C9H16O4

Formula Wt.

188.22

Chemical Name

Nonanedioic acid

IUPAC Name

nonanedioic acid

Synonym

1,7-heptanedicarboxylic acid; Anchoic acid; Azelex

Melting Point

106.5°C

Solubility

Soluble in boiling water and alcohol

Appearance

A White Crystalline Powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

Info Sheet

A9817 Info Sheet PDF

References

Coda AB, Hata T, Miller J, et al. Cathelicidin, kallikrein 5, and serine protease activity is inhibited during treatment of rosacea with azelaic acid 15% gel. J Am Acad Dermatol. 2013 Oct;69(4):570-7. PMID: 23871720.

Briganti S, Flori E, Mastrofrancesco A, et al. Azelaic acid reduced senescence-like phenotype in photo-irradiated human dermal fibroblasts: possible implication of PPARγ. Exp Dermatol. 2013 Jan;22(1):41-7. PMID: 23278893.

Fitton A, Goa KL. Azelaic acid. A review of its pharmacological properties and therapeutic efficacy in acne and hyperpigmentary skin disorders. Drugs. 1991 May;41(5):780-98. PMID: 1712709.

品牌介绍
LKT Labs LKT Labs 是一家专注于防癌抗癌特殊化学品研究和开发的公司。主要提供:癌症药物、药物发现试剂盒、天然产物、广泛的生命科学研究试剂、定制合成。美国LKT Labs 是1988年在美国成立的,为全球提供先端的药物研发试剂、试剂盒、委托合成,并为药物生产企业提供原料,最近几年在农药、水产养殖业有很大程度的开发。在LKT Labs 可以找到在其他地方找不到的产品。 试剂