BestatinisadipeptideinhibitorofaminopeptidasessuchasaminopeptidaseN/CD13.Bestatindisplaysefficacyinthetreatmentoflungcancer.Thiscompoundexhibitsanticancerchemotherapeutic,immunomodulatory,andanalgesicactivities.Bestatinenhancesdifferentiationofacutepromyelocyticleukemia(APL)cells.Additionally,bestatinenhancesproliferationofbonemarrowmacrophageProgenitorcellsandformationofCFU-GMcolonies.Thiscompoundalsoinhibitscatabolismofopioidendopeptides.
| CasNo. | 65391-42-6 |
|---|---|
| Purity | ≥98% |
| Formula | C16H24N2O4•HCl |
| FormulaWt. | 344.87 |
| ChemicalName | N-[(2S,3R)-3-Amino-2-hydroxy-1-oxo-4-phenylbutyl]-L-leucinehydrochloride |
| IUPACName | (2S)-2-[[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoyl]amino]-4-methylpentanoicacid;hydrochloride |
| Synonym | Ubenimexhydrochloride |
| MeltingPoint | 216-218°C |
| Solubility | Solubleinwater(25mg.mL). |
| Appearance | WhiteCrystalPowder |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| MSDS | B1874MSDSPDF |
|---|---|
| InfoSheet | B1874InfoSheetPDF |
HitzerdSM,VerbruggeSE,OssenkoppeleG,etal.Positioningofaminopeptidaseinhibitorsinnextgenerationcancertherapy.AminoAcids.2014Apr;46(4):793-808.PMID:24385243.
QianX,HeJ,ZhaoY,etal.Inhibitionofp38MAPKPhosphorylationIsCriticalforBestatintoEnhanceATRA-InducedCellDifferentiationinAcutePromyelocyticLeukemiaNB4Cells.AmJTher.2013Oct17.[Epubaheadofprint].PMID:24141198.
JiaMR,WeiT,XuWF.TheAnalgesicActivityofBestatinasaPotentAPNInhibitor.FrontNeurosci.2010Jun28;4:50.PMID:20631848.
