Tolmetinisapyrrolenon-steroidalanti-inflammatorydrug(NSAID)thatexhibitsanti-inflammatoryandanalgesicactivities.TolmetininhibitsCOX-1andCOX-2,preventingprostaglandinE(PGE)production;itisclinicallyusedtotreatrheumatoidarthritisandosteoarthritis.
| CasNo. | 64490-92-2 |
|---|---|
| Purity | ≥98% |
| Formula | C15H14NNaO3•2H2O |
| FormulaWt. | 315.30 |
| ChemicalName | 1-Methyl-5-(4-methylbenzoyl)-1H-pyrrole-2-aceticacidsodiumsaltdihydrate |
| IUPACName | sodium;2-[1-methyl-5-(4-methylbenzoyl)pyrrol-2-yl]acetate |
| Synonym | Tolmetinsodiumsaltdihydrate;Reutol;Tolectine;Tolmene |
| MeltingPoint | 155-157(dec.) |
| Solubility | Solubleinwater. |
| StoreTemp | Ambient |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | T5944InfoSheetPDF |
|---|
FernandesE,CostaD,TosteSA,etal.Invitroscavengingactivityforreactiveoxygenandnitrogenspeciesbynonsteroidalanti-inflammatoryindole,pyrrole,andoxazolederivativedrugs.FreeRADIcBiolMed.2004Dec1;37(11):1895-905.PMID:15528048.
DaviesJ,DixonAS,SteeleCE.Tolmetinsodiumandindomethacininthetreatmentofosteoarthrosisofthehip:adouble-blindcrossoverstudy.CurrMedResOpin.1980;7(2):115-20.PMID:7002480.
CordreyLJ.Tolmetinsodium,anewanti-arthritisdrug:double-blindandlong-termstudies.JAmGeriatrSoc.1976Oct;24(10):440-6.PMID:61224.
