LKT/SULINDAC SULFIDE/S8147/100 mg-免疫在线蚂蚁淘旗下平台

商品详细LKT/SULINDAC SULFIDE/S8147/100 mg

LKT/SULINDAC SULFIDE/S8147/100 mg

商品编号： S8147-100mg

品牌： lktlabs

市场价： ¥7560.00

美元价： 4536.00

产地：美国(厂家直采)

公司：

产品分类：临床研究

公司分类： clinical_research

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

ProductIDS8147

CasNo.32004-67-4

Purity≥98%

Description
ProductInfo
ShippingandStorage
Downloads
References

Description

Sulindacisanon-steroidalanti-inflammatorydrug(NSAID)thatinhibitsCOX-1andCOX-2.Sulindacexhibitsanti-inflammatory,neuroprotective,anti-metastatic,andanticancerchemotherapeuticactivities.Invitro,sulindacinhibitsphosphodiesterases(PDEs),increasinglevelsofcGMPandactivationofPKGandinhibitingexpressionofβ-catenin.Inanimalmodelsofischemicstroke,sulindacdecreasesinfarctsizeandincreasesexpressionofAkt,Bcl-2,andHSP27.ThiscompoundinhibitsinvasionofbreastcancercellsandcoloncancercellsbydecreasingNF-κB-mediatedtranscriptionofseveralmiRNAs.Additionally,sulindacdownregulatesexpressionofSTAT3andsurvivinanddecreasescellproliferationandtumorgrowthincellularandanimalmodelsoflaryngealcancer.

ProductInfo

CasNo.	32004-67-4
Purity	≥98%
Formula	C₂₀H₁₇FO₂S
FormulaWt.	340.41
ChemicalName	1H-Indene-3-aceticacid,5-fluoro-2-methyl-1-(p-(methylthio)benzylidene)-
IUPACName	2-[6-fluoro-2-methyl-3-[(4-methylsulfanylphenyl)methylidene]inden-1-yl]aceticacid
MeltingPoint	186-188°C
Solubility	SolubleinDMSO(>20mg/mL)orethanol.
Appearance	BrightYellowCrystals

ShippingandStorage

StoreTemp	Ambient
ShipTemp	Ambient

Downloads

MSDS	S8147MSDSPDF
InfoSheet	S8147InfoSheetPDF

References

ModiJP,GharibaniPM,MaZ,etal.Protectivemechanismofsulindacinananimalmodelofischemicstroke.BrainRes.2014Aug12;1576:91-9.PMID:24968090.

LiN,XiY,TinsleyHN,etal.SulindacselectivelyinhibitscolontumorcellgrowthbyactivatingthecGMP/PKGpathwaytosuppressWnt/β-cateninsignaling.MolCancerTher.2013Sep;12(9):1848-59.PMID:23804703.

LiX,GaoL,CuiQ,etal.SulindacinhibitstumorcellinvasionbysuppressingNF-κB-mediatedtranscriptionofmicroRNAs.Oncogene.2012Nov29;31(48):4979-86.PMID:22286762.

ScheperMA,NikitakisNG,ChaisuparatR,etal.Sulindacinducesapoptosisandinhibitstumorgrowthinvivoinheadandnecksquamouscellcarcinoma.Neoplasia.2007Mar;9(3):192-9.PMID:17401459.

品牌介绍

LKT Labs LKT Labs 是一家专注于防癌抗癌特殊化学品研究和开发的公司。主要提供：癌症药物、药物发现试剂盒、天然产物、广泛的生命科学研究试剂、定制合成。美国LKT Labs 是1988年在美国成立的，为全球提供先端的药物研发试剂、试剂盒、委托合成，并为药物生产企业提供原料，最近几年在农药、水产养殖业有很大程度的开发。在LKT Labs 可以找到在其他地方找不到的产品。试剂